Evidence map›Paper›PMID 31359618›Full record

ReviewCNS neuroscience & therapeutics2019

Risk factors for hemorrhage of brain arteriovenous malformation.

Sonali S Shaligram, Ethan Winkler, Daniel Cooke, Hua Su

Abstract readReview
In one paragraph

Review in CNS neuroscience & therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Translational relevance of animal models available on brain arteriovenous malformations, a systematic review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Pooled it
  2. Pooled it
  3. Article
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  5. Mutant KRAS in brain endothelial cells promotes vascular inflammation and impairs vascular integrity in brain arteriovenous malformation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
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  15. Vessel wall imaging and quantitative flow assessment in arteriovenous malformations: A feasibility study.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sonali S ShaligramCenter for Cerebrovascular Research, Department of Anesthesia and Perioperative care, University of California, San Francisco, California.
Ethan WinklerDepartment of Neurological Surgery, University of California, San Francisco, California.
Daniel CookeDepartment of Radiology, University of California, San Francisco, California.
Hua SuCenter for Cerebrovascular Research, Department of Anesthesia and Perioperative care, University of California, San Francisco, California.ORCID 0000-0003-1566-9877

Funding

Uncover the Pathogenesis of Brain Arteriovenous MalformationR01NS027713 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SU, HUA · 1990 to 2023
$8.6M
Cell type-specific influences on HHT pathogenesisR01HL122774 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SU, HUA · 2015 to 2018
$1.6M
NHLBI NIH HHS R01 HL122774NINDS NIH HHS R01 NS027713
6 · The paper itself

Abstract

Patients with brain arteriovenous malformation (bAVM) are at risk of intracranial hemorrhage (ICH). Overall, bAVM accounts for 25% of hemorrhagic strokes in adults <50 years of age. The treatment of unruptured bAVMs has become controversial, because the natural history of these patients may be less morbid than invasive therapies. Available treatments include observation, surgical resection, endovascular embolization, stereotactic radiosurgery, or combination thereof. Knowing the risk factors for bAVM hemorrhage is crucial for selecting appropriate therapeutic strategies. In this review, we discussed several biological risk factors, which may contribute to bAVM hemorrhage.

Indexed as

Arteriovenous FistulaBlood-Brain BarrierEmbolization, TherapeuticHumansIntracranial Arteriovenous MalformationsIntracranial HemorrhagesRadiosurgeryRisk FactorsVascular Endothelial Growth Factor AVascular Endothelial Growth Factor AVEGFA protein, humanbrain arteriovenous malformationhemodynamicintracranial hemorrhagevascular endothelial growth factorvascular integrity

Identifiers

PMID31359618
PMCPMC6776739

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.