Evidence map›Paper›PMID 31359613›Full record

ArticleCancer medicine2019

Effect of chronic lymphocytic thyroiditis on the efficacy and safety of ultrasound-guided radiofrequency ablation for papillary thyroid microcarcinoma.

Yan Zhang, Ming-Bo Zhang, Yu-Kun Luo, Jie Li, Ying Zhang, Jie Tang

Open access · goldAbstract read
In one paragraph

Article in Cancer medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 4 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Ablative Technologies for Thyroid Nodules: A Health Technology Assessment.Ontario health technology assessment series · 2026
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  11. [Clinical application of the disposable incision retractor fixator in resection for papillary thyroid carcinoma].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yan ZhangDepartment of Ultrasound, Chinese People's Liberation Army General Hospital, Beijing, China.
Ming-Bo ZhangDepartment of Ultrasound, Chinese People's Liberation Army General Hospital, Beijing, China.
Yu-Kun LuoDepartment of Ultrasound, Chinese People's Liberation Army General Hospital, Beijing, China.ORCID https://orcid.org/0000-0003-4280-8713
Jie LiDepartment of Pathology, Chinese People's Liberation Army General Hospital, Beijing, China.
Ying ZhangDepartment of Ultrasound, Chinese People's Liberation Army General Hospital, Beijing, China.
Jie TangDepartment of Ultrasound, Chinese People's Liberation Army General Hospital, Beijing, China.
People's Liberation Army No. 150 Hospital · CNChinese People's Liberation Army · CN

Funding

National natural Science Foundation of China 81771834Natural Science Foundation of Beijing, China 7194318
6 · The paper itself

Abstract

backgroundChronic lymphocytic thyroiditis (CLT) is an autoimmune disease commonly associated with papillary thyroid carcinoma characterized by a smaller primary tumor size at presentation. The efficacy and safety of ultrasound-guided radiofrequency ablation (RFA) for papillary thyroid microcarcinoma (PTMC) coexisting with CLT is still unknown.

methodsSixty patients with unifocal PTMC were enrolled and classified into PTMC and PTMC+CLT groups (n = 30/group). CLT was diagnosed histopathologically. The ablation area exceeded the tumor margins, and was evaluated by US and contrast-enhanced US (CEUS) for residual tumor to prevent recurrence. Three months after ablation, US-guided core-needle biopsy was performed to assess the presence of residual and recurrent cancer. Preoperative and postoperative data on patients and tumors were recorded and analyzed.

resultsThere were no differences between groups in age, sex, preoperative tumor volume, ablation time, or ablation power (P > 0.05). There was also no significant difference in postoperative ablation zone volume between the groups at the 1-, 3-, 6-, 12-, and 18-month follow-ups (P > 0.05). The volume reduction rate significantly differed between the two groups at month 3 (P = 0.03). The ablation area could not be identified on US and CEUS at 9.8 ± 5.0 and 10.0 ± 4.8 months in the PTMC and PTMC + CLT groups, respectively (P = 0.197). No serious complications occurred during and after ablation. No residual cancer cells were found on biopsy after ablation.

conclusionsRFA was effective in patients with PTMC+CLT, and its therapeutic efficacy and safety were similar to those in patients with PTMC without CLT.

Indexed as

AdultCarcinoma, PapillaryCatheter AblationComorbidityEndoscopic Ultrasound-Guided Fine Needle AspirationFemaleHashimoto DiseaseHumansMaleNeoplasm Recurrence, LocalSurvival AnalysisThyroid NeoplasmsTreatment Outcomeablationcontrast mediaradiofrequencythyroid carcinoma; ultrasonography

Identifiers

PMID31359613
PMCPMC6746112
OpenAlexW2977080223

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.