Evidence map›Paper›PMID 31359403›Full record

ArticleJournal of endocrinological investigation2019

One-year caloric restriction and 12-week exercise training intervention in obese adults with type 2 diabetes: emphasis on metabolic control and resting metabolic rate.

F Zurlo, C Trevisan, N Vitturi, E Ravussin, C Salvò, S Carraro, M Siffi, I Iob, A Saller, L Previato and 4 more

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03785379 (A Randomized Trial Evaluating the Effects of One-Year Caloric Restriction and 12-Week Exercise Training Intervention in Obese Adults With Type 2 Diabetes), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03785379 nacompletednot on this map

A Randomized Trial Evaluating the Effects of One-Year Caloric Restriction and 12-Week Exercise Training Intervention in Obese Adults With Type 2 Diabetes: Emphasis on Metabolic Control and Resting Metabolic Rate

TypeinterventionalSponsorUniversity of PadovaRan2013 to 2015Enrolled23ConditionsType 2 Diabetes MellitusArmsCaloric restriction, Exercise training
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Antidiabetic Effects of Physical Activity: How It Helps to Control Type 2 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

F ZurloMetabolic Unit, Department of Medicine, University of Padua, via Giustiniani 2, 35128, Padua, Italy.
C TrevisanGeriatrics Division, Department of Medicine, University of Padua, via Giustiniani 2, 35128, Padua, Italy. caterina.trevisan.5@phd.unipd.it.
N VitturiMetabolic Unit, Department of Medicine, University of Padua, via Giustiniani 2, 35128, Padua, Italy.
E RavussinDivision of Clinical Sciences Pennington, Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.
C SalvòMetabolic Unit, Department of Medicine, University of Padua, via Giustiniani 2, 35128, Padua, Italy.
S CarraroGeriatrics Division, Department of Medicine, University of Padua, via Giustiniani 2, 35128, Padua, Italy.
M SiffiForum Wellness Club, Via Savelli 120, 35129, Padua, Italy.
I IobMetabolic Unit, Department of Medicine, University of Padua, via Giustiniani 2, 35128, Padua, Italy.
A SallerDepartment of Medicine, Clinica Medica 1, University of Padua, via Giustiniani 2, 35128, Padua, Italy.
L PreviatoDepartment of Medicine, Clinica Medica 1, University of Padua, via Giustiniani 2, 35128, Padua, Italy.
G SergiGeriatrics Division, Department of Medicine, University of Padua, via Giustiniani 2, 35128, Padua, Italy.
S de KreutzenbergMetabolic Unit, Department of Medicine, University of Padua, via Giustiniani 2, 35128, Padua, Italy.
A MaranMetabolic Unit, Department of Medicine, University of Padua, via Giustiniani 2, 35128, Padua, Italy.
A AvogaroMetabolic Unit, Department of Medicine, University of Padua, via Giustiniani 2, 35128, Padua, Italy.
University of Padua · ITPennington Biomedical Research Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe effect of combined lifestyle interventions (LSI) including dietary and physical activity on metabolic health, energy metabolism and VO

methodsAfter 1-month education for LSI, 33 participants had anthropometric, biochemical and metabolic assessments. They then started CR based on RMR, and 3-month SSET during the months 1-3 (Early-SSET) or 4-6 (Late-SSET). Reassessments were planned after 3, 6 and 12 months. Using a per-protocol analysis, we evaluated parameter changes from baseline and their associations for the 23 participants (11 Early-SSET, 12 Late-SSET) who completed the study. RMR was adjusted (adjRMR) for age, sex, fat-free mass (FFM) and fat mass (FM).

resultsCompared with baseline, after 6 months we found significant increases in VO

conclusionsCombined intervention with SSET and CR improved metabolic control. Changes in metabolic health and fitness correlated with changes of adjRMR, which was reduced improving fitness, glycemia and cholesterolemia. CLINICAL TRIAL REGISTRY: Trial registration number: NCT03785379. URL of registration: http://clinicaltrials.gov .

Indexed as

Caloric RestrictionExercise TherapyBasal MetabolismBody WeightDiabetes Mellitus, Type 2Diet, ReducingEnergy MetabolismFemaleHumansLife StyleMaleMiddle AgedObesityCaloric restriction dietObesityResting metabolic rateStructured exerciseType 2 diabetes

Identifiers

PMID31359403
OpenAlexW2966690899

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.