Evidence map›Paper›PMID 31359243›Full record

ArticleMolecular and cellular biochemistry2019

Effects of different dietary regimes alone or in combination with standardized Aronia melanocarpa extract supplementation on lipid and fatty acids profiles in rats.

Petar Milic, Jovana Jeremic, Vladimir Zivkovic, Ivan Srejovic, Nevena Jeremic, Jovana Bradic, Tamara Nikolic Turnic, Isidora Milosavljevic, Sergey Bolevich, Stefani Bolevich and 5 more

Abstract read
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In one paragraph

Article in Molecular and cellular biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Effects of Chokeberries (Journal of clinical medicine · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Petar MilicHigh Medical School of Professional Studies in Cuprija, Lole Ribara 1/2, Cuprija, 35 000, Serbia.
Jovana JeremicDepartment of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, Kragujevac, 34 000, Serbia.
Vladimir ZivkovicDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, Kragujevac, 34 000, Serbia.
Ivan SrejovicDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, Kragujevac, 34 000, Serbia.
Nevena JeremicDepartment of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, Kragujevac, 34 000, Serbia.
Jovana BradicDepartment of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, Kragujevac, 34 000, Serbia.
Tamara Nikolic TurnicDepartment of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, Kragujevac, 34 000, Serbia.
Isidora MilosavljevicDepartment of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, Kragujevac, 34 000, Serbia.
Sergey BolevichDepartment of Human Pathology, 1st Moscow State Medical, University IM Sechenov, Trubetskaya street 8, Moscow, Russia, 119991.
Stefani BolevichDepartment of Pathophysiology, 1st Moscow State Medical, University IM Sechenov, Trubetskaya street 8, Moscow, Russia, 119991.
Milica Labudovic BorovicInstitute of Histology and Embryology "Aleksandar Dj. Kostic", Faculty of Medicine, University of Belgrade, Dr Subotic 8, Belgrade, 11 000, Serbia.
Aleksandra ArsicInstitute for Medical Research, Centre of Research Excellence in Nutrition and Metabolism, University of Belgrade, Tadeusa Koscuska 1, Belgrade, 11 129, Serbia.
Miroslav MitrovicPharmanova, Generala Anrija 6, Belgrade, 11 010, Serbia.
Vladimir JakovljevicDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, Kragujevac, 34 000, Serbia. drvladakgbg@yahoo.com.ORCID http://orcid.org/0000-0002-0071-8376
Vesna VucicInstitute for Medical Research, Centre of Research Excellence in Nutrition and Metabolism, University of Belgrade, Tadeusa Koscuska 1, Belgrade, 11 129, Serbia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated different dietary strategies, high-fat (HFd), or standard diet (Sd) alone or in combination with standardized Aronia melanocarpa extract (SAE), as a polyphenol-rich diet, and their effects on lipids and fatty acids (FA) in rats with metabolic syndrome (MetS). Wistar albino rats were randomly divided into two groups: healthy and rats with MetS, and then depending on dietary patterns on six groups: healthy rats fed with Sd, healthy rats fed with Sd and SAE, rats with MetS fed with HFd, rats with MetS fed with HFd and SAE, rats with MetS fed with Sd, and rats with MetS fed with Sd and SAE. 4 weeks later, after an overnight fast (12-14 h), blood for determination of total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), index of lipid peroxidation (measured as TBARS), and FA was collected. Increased FA and lipid concentration found in MetS rats were reduced when changing dietary habits from HFd to Sd with or without SAE consumption. Consumption of SAE slightly affects the FA profiles, mostly palmitoleic acid in healthy rats and PUFA in MetS + HFd rats. Nevertheless, in a high-fat diet, SAE supplementation significantly decreases n-6/n-3 ratio, thereby decreasing systemic inflammation. Further researches are warranted to confirm these effects in humans.

Indexed as

DietDietary SupplementsAnimalsFatty Acid DesaturasesFatty Acid ElongasesFatty AcidsMalePhotiniaPlant ExtractsRats, WistarFatty Acid DesaturasesFatty Acid ElongasesFatty AcidsPlant ExtractsAronia melanocarpaDietary patternFatty acidsLipid profilesMetabolic syndrome

Identifiers

PMID31359243

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.