Trial reportClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020
Cost-effectiveness of an Environmental Cleaning Bundle for Reducing Healthcare-associated Infections.
Trial report in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Economic Evaluation of Enhanced Cleaning and Disinfection of Shared Medical Equipment.JAMA network open · 2025Trial
- Effectiveness of a structured, framework-based approach to implementation: the Researching Effective Approaches to Cleaning in Hospitals (REACH) Trial.Antimicrobial resistance and infection control · 2020Trial
- Filamentous surface structures drive biofilm formation in ICU-isolatedMicrobiology spectrum · 2026Article
- Effectiveness of nursing interventions on preventing the risk of infection in hospitalized adults: a systematic review.BMC nursing · 2026Article
- Predictive Modeling for Clostridioides difficile Infection: Current State of the Science, Clinical Applications, and Future Directions.Infectious disease clinics of North America · 2025Review
- Public Health Center Strategies to Develop Infection Control Practices for Hospital Sinks in Kawaguchi City.Cureus · 2025Article
- Electrospinning Enables Opportunity for Green and Effective Antibacterial Coatings of Medical Devices.Journal of functional biomaterials · 2025Review
- Experimental modelling of failure risks using wipe dispenser systems and ready-to-use disinfecting wipes and their consequences.GMS hygiene and infection control · 2025Article
- Uptake of health economic evaluations alongside clinical trials in Australia: an observational study.Trials · 2024Observational
- 16S rRNA amplicon sequencing and antimicrobial resistance profile of intensive care units environment in 41 Brazilian hospitals.Frontiers in public health · 2024Observational
- Implementation of a novel color additive for bleach disinfectant wipes enhances cleaning performance in an academic medical center.Infection control and hospital epidemiology · 2023Article
- Multimodal environmental cleaning strategies to prevent healthcare-associated infections.Antimicrobial resistance and infection control · 2023Article
- Hospital cleaning: past, present, and future.Antimicrobial resistance and infection control · 2023Review
- Evaluation of the characteristics of infection prevention and control programs and infection control committees in Brazilian hospitals: A countrywide cross-sectional study.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2023Article
- Environmental cleaning and disinfection: Sustaining changed practice and improving quality in the community hospital.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2022Article
- A pre-pandemic COVID-19 assessment of the costs of prevention and control interventions for healthcare associated infections in medical and surgical wards in Québec.Antimicrobial resistance and infection control · 2021Observational
- Long-term antimicrobial effectiveness of a silver-impregnated foil on high-touch hospital surfaces in patient rooms.Antimicrobial resistance and infection control · 2021Article
- Cost-effectiveness analysis of whole-genome sequencing during an outbreak of carbapenem-resistantAntimicrobial stewardship & healthcare epidemiology : ASHE · 2021Article
- Chemical disinfection in healthcare settings: critical aspects for the development of global strategies.GMS hygiene and infection control · 2020Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHealthcare-associated infections (HAIs) remain a significant patient safety issue, with point prevalence estimates being ~5% in high-income countries. In 2016-2017, the Researching Effective Approaches to Cleaning in Hospitals (REACH) study implemented an environmental cleaning bundle targeting communication, staff training, improved cleaning technique, product use, and audit of frequent touch-point cleaning. This study evaluates the cost-effectiveness of the environmental cleaning bundle for reducing the incidence of HAIs.
methodsA stepped-wedge, cluster-randomized trial was conducted in 11 hospitals recruited from 6 Australian states and territories. Bundle effectiveness was measured by the numbers of Staphylococcus aureus bacteremia, Clostridium difficile infection, and vancomycin-resistant enterococci infections prevented in the intervention phase based on estimated reductions in the relative risk of infection. Changes to costs were defined as the cost of implementing the bundle minus cost savings from fewer infections. Health benefits gained from fewer infections were measured in quality-adjusted life-years (QALYs). Cost-effectiveness was evaluated using the incremental cost-effectiveness ratio and net monetary benefit of adopting the cleaning bundle over existing hospital cleaning practices.
resultsImplementing the cleaning bundle cost $349 000 Australian dollars (AUD) and generated AUD$147 500 in cost savings. Infections prevented under the cleaning bundle returned a net monetary benefit of AUD$1.02 million and an incremental cost-effectiveness ratio of $4684 per QALY gained. There was an 86% chance that the bundle was cost-effective compared with existing hospital cleaning practices.
conclusionsA bundled, evidence-based approach to improving hospital cleaning is a cost-effective intervention for reducing the incidence of HAIs.
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