Evidence map›Paper›PMID 31358989›Full record

ArticleNature neuroscience2019

Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans.

Joel Gelernter, Ning Sun, Renato Polimanti, Robert Pietrzak, Daniel F Levey, Julien Bryois, Qiongshi Lu, Yiming Hu, Boyang Li, Krishnan Radhakrishnan and 18 more

Abstract read
In one paragraph

Article in Nature neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 135 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
135citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

135 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  11. Neuropsychiatry genetics in Africa.Nature communications · 2026
    Review
  12. Article
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  16. Mice lacking two alleles of the schizophrenia risk geneFrontiers in cellular neuroscience · 2026
    Article
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75 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Joel Gelernter *Psychiatry Service, VA Connecticut Healthcare System, West Haven, CT, USA. joel.gelernter@yale.edu.ORCID http://orcid.org/0000-0002-4067-1859
Ning SunVA Clinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, CT, USA.
Renato PolimantiPsychiatry Service, VA Connecticut Healthcare System, West Haven, CT, USA.
Robert PietrzakPsychiatry Service, VA Connecticut Healthcare System, West Haven, CT, USA.
Daniel F LeveyPsychiatry Service, VA Connecticut Healthcare System, West Haven, CT, USA.
Julien BryoisDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-4747-2166
Qiongshi LuDepartment of Biostatistics, Yale University School of Public Health, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-4514-0969
Yiming HuDepartment of Biostatistics, Yale University School of Public Health, New Haven, CT, USA.
Boyang LiDepartment of Biostatistics, Yale University School of Public Health, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-2808-9986
Krishnan RadhakrishnanVA Clinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, CT, USA.
Mihaela AslanVA Clinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, CT, USA.
Kei-Hoi CheungVA Clinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, CT, USA.
Yuli LiVA Clinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, CT, USA.
Nallakkandi RajeevanVA Clinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, CT, USA.ORCID http://orcid.org/0000-0002-2045-0872
Frederick SaywardVA Clinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, CT, USA.
Kelly HarringtonMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
Quan ChenVA Clinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, CT, USA.
Kelly ChoMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
Saiju PyarajanMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
Patrick F SullivanDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-6619-873X
Rachel QuadenMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
Yunling ShiMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
Haley Hunter-ZinckMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
J Michael GazianoMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
John ConcatoVA Clinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, CT, USA.
Hongyu ZhaoVA Clinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, CT, USA.ORCID http://orcid.org/0000-0003-1195-9607
Murray B Stein *Psychiatry Service, VA San Diego Healthcare System, San Diego, CA, USA.ORCID http://orcid.org/0000-0001-9564-2871
Department of Veterans Affairs Cooperative Studies Program (#575B) and Million Veteran Program

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Post-traumatic stress disorder (PTSD) is a major problem among military veterans and civilians alike, yet its pathophysiology remains poorly understood. We performed a genome-wide association study and bioinformatic analyses, which included 146,660 European Americans and 19,983 African Americans in the US Million Veteran Program, to identify genetic risk factors relevant to intrusive reexperiencing of trauma, which is the most characteristic symptom cluster of PTSD. In European Americans, eight distinct significant regions were identified. Three regions had values of P < 5 × 10

Indexed as

AdultCohort StudiesFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleStress Disorders, Post-TraumaticUnited StatesVeteransVeterans Health

Identifiers

PMID31358989
PMCPMC6953633

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.