Evidence map›Paper›PMID 31358984›Full record

ArticleNature microbiology2019

Entry of the bat influenza H17N10 virus into mammalian cells is enabled by the MHC class II HLA-DR receptor.

Efstathios S Giotis, George Carnell, Erik F Young, Saleena Ghanny, Patricia Soteropoulos, Lin-Fa Wang, Wendy S Barclay, Michael A Skinner, Nigel Temperton

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Nature microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 59 citations in OpenAlex.

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  18. Serological evidence of virus infection inFrontiers in public health · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Efstathios S GiotisSection of Virology, Department of Medicine, Imperial College London, London, UK. e.giotis@imperial.ac.uk.ORCID http://orcid.org/0000-0001-8908-7824
George CarnellViral Pseudotype Unit, Medway School of Pharmacy, University of Kent and University of Greenwich, Chatham, UK.ORCID http://orcid.org/0000-0001-8875-0989
Erik F YoungDepartment of Surgery, Hackensack University Medical Center, Hackensack, NJ, USA.ORCID http://orcid.org/0000-0002-7980-1251
Saleena GhannyThe Genomics Center, New Jersey Medical School, Rutgers University, Newark, NJ, USA.ORCID http://orcid.org/0000-0001-6922-1862
Patricia SoteropoulosThe Genomics Center, New Jersey Medical School, Rutgers University, Newark, NJ, USA.
Lin-Fa WangProgramme in Emerging Infectious Disease, Duke-NUS Medical School, Singapore, Singapore.ORCID http://orcid.org/0000-0003-2752-0535
Wendy S BarclaySection of Virology, Department of Medicine, Imperial College London, London, UK.
Michael A SkinnerSection of Virology, Department of Medicine, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-0050-4167
Nigel TempertonViral Pseudotype Unit, Medway School of Pharmacy, University of Kent and University of Greenwich, Chatham, UK.
Imperial College London · GBMedway School of Pharmacy · GBRutgers, The State University of New Jersey · USDuke-NUS Medical School · SGHackensack University Medical Center · US

Funding

Biotechnology and Biological Sciences Research Council BB/K002465/1
6 · The paper itself

Abstract

Haemagglutinin and neuraminidase surface glycoproteins of the bat influenza H17N10 virus neither bind to nor cleave sialic acid receptors, indicating that this virus employs cell entry mechanisms distinct from those of classical influenza A viruses. We observed that certain human haematopoietic cancer cell lines and canine MDCK II cells are susceptible to H17-pseudotyped viruses. We identified the human HLA-DR receptor as an entry mediator for H17 pseudotypes, suggesting that H17N10 possesses zoonotic potential.

Indexed as

Viral TropismVirus InternalizationAnimalsChiropteraDogsHEK293 CellsHLA-DR AntigensHumansMadin Darby Canine Kidney CellsMicroarray AnalysisOrthomyxoviridaeReceptors, VirusZoonosesHLA-DR AntigensReceptors, Virus

Identifiers

PMID31358984
OpenAlexW2966840980

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.