Evidence map›Paper›PMID 31358913›Full record

ArticleThe Journal of antibiotics2019

2-Pyrazol-1-yl-thiazole derivatives as novel highly potent antibacterials.

Yan A Ivanenkov, Renat S Yamidanov, Ilya A Osterman, Petr V Sergiev, Vladimir A Aladinskiy, Anastasia V Aladinskaya, Victor A Terentiev, Mark S Veselov, Andrey A Ayginin, Dmitry A Skvortsov and 12 more

Abstract read
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In one paragraph

Article in The Journal of antibiotics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Yan A IvanenkovInstitute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russia.
Renat S YamidanovInstitute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russia.
Ilya A OstermanLomonosov Moscow State University, Chemistry Department, Leninskie Gory, Building 1/3, GSP-1, 119991, Moscow, Russia.
Petr V SergievSkolkovo Institute of Science and Technology, Skolkovo, Russia.
Vladimir A AladinskiyMoscow Institute of Physics and Technology (State University), 9 Institutskiy Lane, Dolgoprudny City, 141700, Moscow, Russia.
Anastasia V AladinskayaMoscow Institute of Physics and Technology (State University), 9 Institutskiy Lane, Dolgoprudny City, 141700, Moscow, Russia. anastasiya.aladinskaya@gmail.com.ORCID http://orcid.org/0000-0003-3173-355X
Victor A TerentievInstitute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russia.
Mark S VeselovInstitute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russia.
Andrey A AygininInstitute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russia.
Dmitry A SkvortsovLomonosov Moscow State University, Department of Chemistry, A.N. Belozersky Institute of Physico-Chemical Biology, Moscow, Russia.
Katerina S KomarovaSkolkovo Institute of Science and Technology, Skolkovo, Russia.
Sergey V SadovnikovInstitute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russia.
Rustam MatniyazovInstitute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russia.
Alina A SofronovaLomonosov Moscow State University, Faculty of Bioengineering and Bioinformatics, Moscow, Russia.
Alexander S MalyshevLomonosov Moscow State University, Faculty of Medicine, Moscow, Russia.
Alexey E MachulkinLomonosov Moscow State University, Chemistry Department, Leninskie Gory, Building 1/3, GSP-1, 119991, Moscow, Russia.
Rostislav A PetrovLomonosov Moscow State University, Chemistry Department, Leninskie Gory, Building 1/3, GSP-1, 119991, Moscow, Russia.
Dmitrii LukianovSkolkovo Institute of Science and Technology, Skolkovo, Russia.
Svetlana IarovenkoSkolkovo Institute of Science and Technology, Skolkovo, Russia.
Dmitry S BezrukovLomonosov Moscow State University, Chemistry Department, Leninskie Gory, Building 1/3, GSP-1, 119991, Moscow, Russia.
Andrey Kh BaymievInstitute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russia.
Olga A DontsovaLomonosov Moscow State University, Chemistry Department, Leninskie Gory, Building 1/3, GSP-1, 119991, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present report describes our efforts to identify new structural classes of compounds having promising antibacterial activity using previously published double-reporter system pDualrep2. This semi-automated high-throughput screening (HTS) platform has been applied to perform a large-scale screen of a diverse small-molecule compound library. We have selected a set of more than 125,000 molecules and evaluated them for their antibacterial activity. On the basis of HTS results, eight compounds containing 2-pyrazol-1-yl-thiazole scaffold exhibited moderate-to-high activity against ΔTolC Escherichia coli. Minimum inhibitory concentration (MIC) values for these molecules were in the range of 0.037-8 μg ml

Indexed as

Anti-Bacterial AgentsCell Line, TumorCell SurvivalHigh-Throughput Screening AssaysHumansMicrobial Sensitivity TestsMolecular StructureThiazolesAnti-Bacterial AgentsThiazoles

Identifiers

PMID31358913

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.