ArticleJournal of perinatology : official journal of the California Perinatal Association2019
Implementation of a probiotic protocol to reduce rates of necrotizing enterocolitis.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Quality improvement interventions to prevent neonatal necrotizing enterocolitis: a systematic review.Frontiers in pediatrics · 2025Pooled it
- Unplanned natural experiment: probiotics prevent necrotizing enterocolitis, a single center quality improvement report.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Contemporary use of prophylactic probiotics in NICUs in the United States: a survey update.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Probiotics for prevention of necrotizing enterocolitis: Where do we stand?Seminars in perinatology · 2023Review
- A prediction model for neonatal necrotizing enterocolitis in preterm and very low birth weight infants.Frontiers in pediatrics · 2023Article
- Enteral supplementation with probiotics in preterm infants: A retrospective cohort study and 6-year follow-up.Frontiers in nutrition · 2022Article
- Key Technologies for Progressing Discovery of Microbiome-Based Medicines.Frontiers in microbiology · 2021Review
- Cost-effectiveness of probiotics for necrotizing enterocolitis prevention in very low birth weight infants.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
- Safety and efficacy of probiotic administration to preterm infants: ten common questions.Pediatric research · 2020Review
- The effect of daily probiotics on the incidence and severity of necrotizing enterocolitis in infants with very low birth weight.Canadian journal of surgery. Journal canadien de chirurgieArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo utilize a probiotic protocol to achieve a 50% reduction in rates of necrotizing enterocolitis (NEC) ≥ Bell Stage 2 within 2 years of protocol implementation. STUDY
designLiterature review guided probiotic selection and protocol design. A driver diagram identified key drivers to achieve our aim. A U chart followed monthly NEC ≥ Bell Stage 2 per 100 patient days and per monthly admissions. The process measure was protocol compliance and the balancing measure was probiotic sepsis.
resultsNEC ≥ Bell Stage 2 decreased from 0.14 to 0.04 per 100 patient days in infants < 33 weeks gestation or <1500 g, or a yearly rate of 7-2%. Protocol compliance was 98% and there were no cases of probiotic sepsis.
conclusionImplementation of a probiotic protocol was associated with a decrease in rates of NEC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.