Particle coating alters mucociliary transit in excised rat trachea: A synchrotron X-ray imaging study.

Mark Gardner, Alexandra McCarron, Kaye Morgan, David Parsons, Martin Donnelley

Open access · goldAbstract read

In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.9field-weighted citation impact, top 23% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

Improved in-vivo airway gene transfer via magnetic-guidance, with protocol development informed by synchrotron imaging.Scientific reports · 2022
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Mark GardnerRobinson Research Institute, University of Adelaide, North Adelaide, SA, 5006, Australia. mark.gardner@adelaide.edu.au.ORCID http://orcid.org/0000-0003-4340-2547

Alexandra McCarronRobinson Research Institute, University of Adelaide, North Adelaide, SA, 5006, Australia.

Kaye MorganSchool of Physics, Monash University, Clayton, Vic, 3800, Australia.

David ParsonsRobinson Research Institute, University of Adelaide, North Adelaide, SA, 5006, Australia.

Martin DonnelleyRobinson Research Institute, University of Adelaide, North Adelaide, SA, 5006, Australia.

Women's and Children's Hospital · AUInstitute for Advanced Study · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have previously developed non-invasive in vivo mucociliary transport (MCT) monitoring methods using synchrotron phase contrast X-ray imaging (PCXI) to evaluate potential therapies for cystic fibrosis (CF). However, previous in vivo measurements of MCT velocity using this method were lower than those from alternate methods. We hypothesise this was due to the surface chemistry of the uncoated particles. We investigated the effect of particle surface coating on MCT marker performance by measuring the velocity of uncoated, positively-charged (aminated; NH

Indexed as

Mucociliary ClearanceAnimalsEquipment DesignFemaleParticle SizeRadiographyRatsRats, WistarSurface PropertiesSynchrotronsTracheaX-Rays

Identifiers

PMID31358851

DOI10.1038/s41598-019-47465-1

PMCPMC6662859

OpenAlexW2965604604

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.