ArticleNature communications2019
A biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroids.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 52 citations in OpenAlex.
- Article
- Rational Design of NiAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A Dynamic Gate Enables Regioselective Hydroxylation of Free Arginine by a Non-Canonical Heme Enzyme.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Chemoenzymatic synthesis of the cardenolide rhodexin A and its aglycone sarmentogenin.Beilstein journal of organic chemistry · 2025Article
- Modification of B-Nor Steroids Mediated by Filamentous FungusInternational journal of molecular sciences · 2024Article
- Strategic application of C-H oxidation in natural product total synthesis.Nature reviews. Chemistry · 2023Review
- Review
- Unravelling and engineering an operon involved in the side-chain degradation of sterols in Mycolicibacterium neoaurum for the production of steroid synthons.Biotechnology for biofuels and bioproducts · 2023Article
- Carboxylic Acid Directed γ-Lactonization of Unactivated Primary C-H Bonds Catalyzed by Mn Complexes: Application to Stereoselective Natural Product Diversification.Journal of the American Chemical Society · 2022Article
- State-of-the-Art Biocatalysis.ACS central science · 2021Review
- Enzymkatalysierte späte Modifizierungen: Besser spät als nie.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2021Review
- Enzymatic Late-Stage Modifications: Better Late Than Never.Angewandte Chemie (International ed. in English) · 2021Review
- Recent trends in biocatalysis.Chemical Society reviews · 2021Review
- Synthetic utility of oxygenases in site-selective terpenoid functionalization.Journal of industrial microbiology & biotechnology · 2021Review
- Extensive expansion of the chemical diversity of fusidane-type antibiotics using a stochastic combinational strategy.Acta pharmaceutica Sinica. B · 2021Article
- Novel Strategies in C-H Oxidations for Natural Product Diversification-A Remote Functionalization Application Summary.Frontiers in chemistry · 2021Review
- Scalable biocatalytic C-H oxyfunctionalization reactions.Chemical Society reviews · 2020Review
- Microbial Modifications of Androstane and Androstene Steroids byMolecules (Basel, Switzerland) · 2020Article
- Recent advances in the chemoenzymatic synthesis of bioactive natural products.Current opinion in chemical biology · 2020Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Steroidal C19-hydroxylation is pivotal to the synthesis of naturally occurring bioactive C19-OH steroids and 19-norsteroidal pharmaceuticals. However, realizing this transformation is proved to be challenging through either chemical or biological synthesis. Herein, we report a highly efficient method to synthesize 19-OH-cortexolone in 80% efficiency at the multi-gram scale. The obtained C
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.