ArticleProceedings of the National Academy of Sciences of the United States of America2019
A selective membrane-targeting repurposed antibiotic with activity against persistent methicillin-resistant
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers.
0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed
11.1field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
110 citing papers in PubMed, 198 citations in OpenAlex.
- Antibacterial efficacy and mechanism of the novel antimicrobial peptide lachnospirin-1 againstVirulence · 2026Article
- Bat-derived antimicrobial peptide MC-CATH3 Confers protection against bacterial infections via a potential ferroptosis-like death process.The Journal of biological chemistry · 2026Article
- The β-lactam adjuvant guanosine potentiates anti-folate antibiotics and pyrimidine synthesis inhibitors by depleting thymidine in methicillin-resistantAntimicrobial agents and chemotherapy · 2026Article
- Modular peptide nanofibres that self-assemble on bacterial membranes overcome antimicrobial resistance.Nature biomedical engineering · 2026Article
- Antibacterial and anti-virulence activity of the repurposed agent SX-682 against Staphylococcus aureus.BMC microbiology · 2026Article
- A Novel Small Molecule Accelerates Early Persister Regrowth and Potentiates Antibiotic Killing via MdtL-DcrB.Microbial biotechnology · 2026Article
- Ιdentification of SQ109 analogs with enhanced antimicrobial activity against methicillin-resistantAntimicrobial agents and chemotherapy · 2026Article
- Candesartan cilexetil disrupts methicillin-resistant Staphylococcus aureus membrane and potentiates gentamicin and polymyxin B activity.Nature communications · 2026Article
- CAMPER: mechanistic artificial intelligence for designing peptides that target MRSA persisters.Nature communications · 2026Article
- The staphylococcal type VII secretion system protein EsxC impacts daptomycin sensitivity through controlling bacterial cell envelope integrity.Journal of bacteriology · 2026Article
- Naturally occurring dinactin targets cpsA protein and kills Mycobacterium tuberculosis by disrupting the proton motive force.Communications biology · 2026Article
- Vm-MSI: a Vancomycin-Antimicrobial Peptide Conjugate Combating Resistant Bacteria and Broadening the Antimicrobial Spectrum.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The β-lactam adjuvant guanosine potentiates anti-folate antibiotics and pyrimidine synthesis inhibitors by depleting thymidine in methicillin-resistantbioRxiv : the preprint server for biology · 2026Article
- Halogenated N-(1,3,4-oxadiazol-2-yl) benzamides are effective eradicators of methicillin-resistant Staphylococcus aureus biofilms.Bioorganic & medicinal chemistry · 2026Article
- Repurposing bunamidine hydrochloride as a potent antimicrobial agent targeting vancomycin-resistantmSystems · 2025Article
- Fangchinoline eliminates intracellular Salmonella by enhancing lysosomal function via the AMPK-mTORC1-TFEB axis.Journal of advanced research · 2025Article
- Drug Repurposing: An Emerging Strategy inJournal of microbiology and biotechnology · 2025Review
- Effective Membrane Permeabilization of Methicillin-ResistantJournal of natural products · 2025Article
- Repurposing Etalocib suppresses multidrug-resistant Staphylococcus aureus by disrupting the bacterial membrane.BMC microbiology · 2025Article
- Proteolytic-resistant self-assembling peptide nanofibers combat specific bacterial infections via trap and kill.Science advances · 2025Article
50 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 5 institutions in 3 countries.
Wooseong KimDivision of Infectious Diseases, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02903.
Guijin ZouSchool of Engineering, Brown University, Providence, RI 02903.
Taylor P A HariDepartment of Chemistry and Emory Antibiotic Resistance Center, Emory University, Atlanta, GA 30322.
Ingrid K WiltDepartment of Chemistry and Emory Antibiotic Resistance Center, Emory University, Atlanta, GA 30322.
Wenpeng ZhuSchool of Engineering, Brown University, Providence, RI 02903.
Nicolas GalleSchool of Engineering, Brown University, Providence, RI 02903.
Hammad A FaiziDepartment of Mechanical Engineering, Northwestern University, Evanston, IL 60208.
Gabriel L HendricksDivision of Infectious Diseases, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02903.
Katerina ToriDivision of Infectious Diseases, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02903.
Wen PanDivision of Infectious Diseases, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02903.
Xiaowen HuangDivision of Infectious Diseases, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02903.
Andrew D SteeleDepartment of Chemistry and Emory Antibiotic Resistance Center, Emory University, Atlanta, GA 30322.
Erika E CsataryDepartment of Chemistry and Emory Antibiotic Resistance Center, Emory University, Atlanta, GA 30322.
Madeline M DekarskeDepartment of Chemistry and Emory Antibiotic Resistance Center, Emory University, Atlanta, GA 30322.
Jake L RosenDepartment of Chemistry and Emory Antibiotic Resistance Center, Emory University, Atlanta, GA 30322.
Noelly de Queiroz RibeiroDepartment of Microbiology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270-901, Brazil.
Kiho LeeDivision of Infectious Diseases, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02903.
Jenna PortDivision of Infectious Diseases, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02903.
Beth Burgwyn FuchsDivision of Infectious Diseases, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02903.
Petia M VlahovskaDepartment of Engineering Sciences and Applied Mathematics, Northwestern University, Evanston, IL 60208.
William M WuestDepartment of Chemistry and Emory Antibiotic Resistance Center, Emory University, Atlanta, GA 30322.ORCID 0000-0002-5198-7744
Huajian GaoSchool of Engineering, Brown University, Providence, RI 02903.ORCID 0000-0002-8656-846X
Frederick M AusubelDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114; ausubel@molbio.mgh.harvard.edu emylonakis@lifespan.org.
Eleftherios MylonakisDivision of Infectious Diseases, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02903; ausubel@molbio.mgh.harvard.edu emylonakis@lifespan.org.ORCID 0000-0002-4624-0777
Brown University · USEmory University · USNorthwestern University · USHarvard University · USUniversidade Federal de Minas Gerais · BR
Funding
Technical Mother Machine CoreP01AI083214 · NIAID · SCHEPENS EYE RESEARCH INSTITUTE · PI Michael S Gilmore · 2009 to 2026
$39.4MUsing Genomic Epidemiology to Identify Transmission Patterns and Inform Intervention Strategies for Antibiotic-Resistant N. GonorrhoeaeP20GM121344 · NIGMS · MIRIAM HOSPITAL · PI MISHRA, BISWAJIT · 2018 to 2022
$9.4MNatural Product-Inspired Approaches Toward The Development Of Antivirulence And Species-Specific InhibitorsR35GM119426 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI William M Wuest · 2016 to 2026
$4.8MNIAID NIH HHS P01 AI083214NIGMS NIH HHS P20 GM121344NIGMS NIH HHS R35 GM119426
Abstract
Treatment of
Indexed as
Drug RepositioningAnimalsAnti-Bacterial AgentsBithionolCell MembraneCell Membrane PermeabilityCholesterolDisease Models, AnimalDrug SynergismGentamicinsLipid BilayersMembrane FluidityMethicillin-Resistant Staphylococcus aureusMolecular Dynamics SimulationPhosphatidylcholinesStructure-Activity Relationship1-palmitoyl-2-oleoylphosphatidylcholineAnti-Bacterial AgentsBithionolCholesterolGentamicinsLipid BilayersPhosphatidylcholinesUnilamellar Liposomesbacterial persisterdrug repurposingmembrane-active antimicrobialsmembrane selectivityMRSA
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What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.