Evidence map›Paper›PMID 31358608›Full record

ArticleJournal of bacteriology2019

Loss of RNA Chaperone Hfq Unveils a Toxic Pathway in Pseudomonas aeruginosa.

Ian T Hill, Thomas Tallo, Matthew J Dorman, Simon L Dove

Open access · bronzeAbstract read
In one paragraph

Article in Journal of bacteriology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Hfq-licensed RNA-RNA interactome inProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  3. Differential Chromosome- and Plasmid-Borne Resistance ofInternational journal of molecular sciences · 2021
    Article
  4. Gene Expression Profiling ofFrontiers in microbiology · 2021
    Article
  5. Article
  6. Hfq-Assisted RsmA Regulation Is Central toFrontiers in microbiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ian T HillDivision of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Thomas TalloDivision of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Matthew J DormanDivision of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Simon L DoveDivision of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA simon.dove@childrens.harvard.edu.
Boston Children's Hospital · USHarvard University · US

Funding

Molecular elucidation of the Francisella tularensis virulence mechanismR01AI154524 · NIAID · DUKE UNIVERSITY · PI BRENNAN, RICHARD GERALD, DOVE, SIMON L · 2021 to 2025
$4.0M
Control of fimbrial gene expression in Pseudomonas aeruginosaR01AI105013 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI DOVE, SIMON L · 2014 to 2018
$2.2M
An essential RNA chaperone in Pseudomonas aeruginosaR21AI125876 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI DOVE, SIMON L · 2017 to 2018
$487k
NIAID NIH HHS R01 AI105013NIAID NIH HHS R01 AI154524NIAID NIH HHS R21 AI125876
6 · The paper itself

Abstract

Hfq is an RNA chaperone that serves as a master regulator of bacterial physiology. Here we show that in the opportunistic pathogen

Indexed as

MutationBacterial ProteinsChromatin ImmunoprecipitationGene Expression Regulation, BacterialGlutathioneHigh-Throughput Nucleotide SequencingHost Factor 1 ProteinMicrobial ViabilityPseudomonas aeruginosaTrans-ActivatorsTranscription FactorsBacterial ProteinsGlutathioneHost Factor 1 ProteinTrans-ActivatorsTranscription Factorschromatin immunoprecipitationglutathioneMexTRNA binding proteinstranscription factorstransposon mutagenesis

Identifiers

PMID31358608
PMCPMC6755729
OpenAlexW2966229742

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.