Evidence map›Paper›PMID 31358594›Full record

ArticleAntimicrobial agents and chemotherapy2019

Efficacy and Safety of Pyronaridine-Artesunate plus Single-Dose Primaquine for the Treatment of Malaria in Western Cambodia.

Rithea Leang, Nimol Khim, Huch Chea, Rekol Huy, Melissa Mairet-Khedim, Denis Mey Bouth, Maria Dorina Bustos, Pascal Ringwald, Benoit Witkowski

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Efficacy, Safety and Tolerability of Pyronaridine-artesunate in Asymptomatic Malaria-infected Individuals: a Randomized Controlled Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Trial
  4. Trial
  5. Review
  6. Review
  7. Review
  8. Article
  9. Observational
  10. Advances and roadblocks in the treatment of malaria.British journal of clinical pharmacology · 2022
    Review
  11. Clinical and In Vitro Resistance of Plasmodium falciparum to Artesunate-Amodiaquine in Cambodia.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  12. Article
  13. Observational
  14. Efficacy and Safety of Pyronaridine-Artesunate for the Treatment of UncomplicatedThe American journal of tropical medicine and hygiene · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rithea LeangNational Center for Parasitology, Entomology & Malaria Control, Phnom Penh, Cambodia rithealeang@gmail.com.
Nimol KhimInstitut Pasteur in Cambodia, Phnom Penh, Cambodia.
Huch CheaNational Center for Parasitology, Entomology & Malaria Control, Phnom Penh, Cambodia.
Rekol HuyNational Center for Parasitology, Entomology & Malaria Control, Phnom Penh, Cambodia.
Melissa Mairet-KhedimInstitut Pasteur in Cambodia, Phnom Penh, Cambodia.
Denis Mey BouthWorld Health Organization, Phnom Penh, Cambodia.
Maria Dorina BustosWorld Health Organization, Bangkok, Thailand.
Pascal RingwaldWorld Health Organization, Geneva, Switzerland.
Benoit WitkowskiInstitut Pasteur in Cambodia, Phnom Penh, Cambodia.

Funding

World Health Organization 001
6 · The paper itself

Abstract

This single-arm trial (

Indexed as

AdolescentAdultAntimalarialsArtesunateCambodiaChildDrug ResistanceFemaleHumansMalariaMaleMiddle AgedNaphthyridinesPlasmodium vivaxPrimaquineYoung AdultAntimalarialsArtesunateNaphthyridinesPrimaquinepyronaridineantimalarial agentsartemisininCambodiadrug resistancemalariaPlasmodium falciparumPlasmodium vivaxpyronaridine-artesunate

Identifiers

PMID31358594
PMCPMC6761550

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.