Evidence map›Paper›PMID 31358581›Full record

ArticleAntimicrobial agents and chemotherapy2019

A Parasite Biomarker Set for Evaluating Benznidazole Treatment Efficacy in Patients with Chronic Asymptomatic Trypanosoma cruzi Infection.

Adriana Egui, M Carmen Thomas, Ana Fernández-Villegas, Elena Pérez-Antón, Inmaculada Gómez, Bartolomé Carrilero, Ángel Del Pozo, Maialen Ceballos, Eduardo Andrés-León, Miguel Ángel López-Ruz and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Observational
  4. Article
  5. Review
  6. Article
  7. Understanding CD8Trends in parasitology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Adriana EguiInstituto de Parasitología y Biomedicina López Neyra, Consejo Superior de Investigaciones Científicas (IPBLN-CSIC), PTS Granada, Granada, Spain.
M Carmen ThomasInstituto de Parasitología y Biomedicina López Neyra, Consejo Superior de Investigaciones Científicas (IPBLN-CSIC), PTS Granada, Granada, Spain mcthomas@ipb.csic.es mclopez@ipb.csic.es.
Ana Fernández-Villegas *Instituto de Parasitología y Biomedicina López Neyra, Consejo Superior de Investigaciones Científicas (IPBLN-CSIC), PTS Granada, Granada, Spain.
Elena Pérez-Antón *Instituto de Parasitología y Biomedicina López Neyra, Consejo Superior de Investigaciones Científicas (IPBLN-CSIC), PTS Granada, Granada, Spain.
Inmaculada Gómez *Instituto de Parasitología y Biomedicina López Neyra, Consejo Superior de Investigaciones Científicas (IPBLN-CSIC), PTS Granada, Granada, Spain.
Bartolomé CarrileroUnidad Regional de Medicina Tropical del Hospital Virgen de la Arrixaca, Murcia, Spain.
Ángel Del PozoBiopraxis Research AIE, Parque Tecnológico de Álava C/Hermanos Lumiere, Álava, Spain.
Maialen CeballosBiokilab S.L., Parque Tecnológico de Álava C/Ferdinand Zeppelin, Álava, Spain.
Eduardo Andrés-LeónInstituto de Parasitología y Biomedicina López Neyra, Consejo Superior de Investigaciones Científicas (IPBLN-CSIC), PTS Granada, Granada, Spain.
Miguel Ángel López-RuzServicio de Medicina Interna, Hospital Virgen de las Nieves, Granada, Spain.
Eusebio GainzaBiopraxis Research AIE, Parque Tecnológico de Álava C/Hermanos Lumiere, Álava, Spain.
Enrique OquiñenaBiokilab S.L., Parque Tecnológico de Álava C/Ferdinand Zeppelin, Álava, Spain.
Manuel SegoviaUnidad Regional de Medicina Tropical del Hospital Virgen de la Arrixaca, Murcia, Spain.
Manuel Carlos LópezInstituto de Parasitología y Biomedicina López Neyra, Consejo Superior de Investigaciones Científicas (IPBLN-CSIC), PTS Granada, Granada, Spain mcthomas@ipb.csic.es mclopez@ipb.csic.es.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One of the current greatest challenges of Chagas disease is the establishment of biomarkers to assess the efficacy of drugs in a short period of time. In this context, the reactivity of sera from 66 adults with chronic indeterminate Chagas disease (IND) for a set of four

Indexed as

AdultBiomarkersCD8-Positive T-LymphocytesChagas DiseaseCytokinesEnzyme-Linked Immunosorbent AssayFemaleGranzymesHumansMaleMiddle AgedNitroimidazolesPerforinPolymerase Chain ReactionTrypanocidal AgentsTrypanosoma cruzibenzonidazoleBiomarkersCytokinesGranzymesNitroimidazolesPerforinTrypanocidal Agentsantibodiesbenznidazolebiomarkerscellular responseChagas diseasecytokinescytotoxic moleculesseroconversiontherapeutic responseTrypanosoma cruzi

Identifiers

PMID31358581
PMCPMC6761566

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.