ArticleThe Journal of experimental medicine2019
Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer.
Open access · bronzeAbstract read
In one paragraph
Article in The Journal of experimental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
80 citing papers in PubMed, 1 synthesis or guideline pooled it, 117 citations in OpenAlex.
- IBD-related inflammatory memory and colorectal cancer: epigenetic mechanisms and microbiome interventions.Frontiers in immunology · 2026Pooled it
- Gut microbiota and diet in colorectal cancer: Converging determinants of carcinogenesis.Gut microbes · 2026Review
- Colitis-associated colorectal carcinogenesis: molecular mechanisms and therapeutic potential.Molecular biomedicine · 2026Review
- Advances in the DMSO reductase family: From discovery to mechanism.Current opinion in chemical biology · 2026Review
- Microbiome-guided cancer immunotherapy: immune mechanisms, resistance pathways, and translational opportunities for precision oncology.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- An anaerobic pathogen rewires host metabolism to fuel oxidative growth in the inflamed gut.Cell · 2026Article
- Akkermansia muciniphila-derived 5-MIAA blunts colitis-associated tumorigenesis by modulating colonic SLC26A3/pSTAT3 signaling.NPJ biofilms and microbiomes · 2026Article
- From inflammation to fibrosis and cancer: the emerging role of AIEC-derived metabolites in intestinal disease progression.Experimental & molecular medicine · 2026Review
- Intestinal oxygen and microbiota crosstalk: implications for pathogenesis of gastrointestinal diseases and emerging therapeutic strategies.Gut pathogens · 2025Review
- Metabolic strategies that enable oral commensal persistence in a lower airway environment.mBio · 2025Article
- Review
- The Microbiota-Diet-Immunity Axis in Cancer Care: From Prevention to Treatment Modulation and Survivorship.Nutrients · 2025Review
- The Emerging Role of the Microbiota and Antibiotics in Diverticulitis Treatment.Clinics in colon and rectal surgery · 2025Review
- Dietary fibre counters the oncogenic potential of colibactin-producing Escherichia coli in colorectal cancer.Nature microbiology · 2025Article
- Genome-scale CRISPR/Cas9 screening reveals the role ofmSphere · 2025Article
- Microbiota and cancer: unraveling the significant influence of microbial communities on cancer treatment.Cancer metastasis reviews · 2025Article
- Gut Microbiota-Mediated hsa_circ_0126925 Targets BCAA Metabolic Enzyme BCAT2 to Exacerbate Colorectal Cancer Progression.Molecular cancer research : MCR · 2025Article
- Phloretin-induced modulation in gut microbiome, mitigates colonic inflammation and alleviates colitis-associated colorectal cancer in mice.Computational and structural biotechnology journal · 2025Article
- The human gut microbiome in health and disease: time for a new chapter?Infection and immunity · 2024Review
- Deciphering the role of host-gut microbiota crosstalk via diverse sources of extracellular vesicles in colorectal cancer.Molecular medicine (Cambridge, Mass.) · 2024Review
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 3 countries.
Wenhan ZhuDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX.
Naoteru MiyataDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX.
Maria G WinterDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX.
Alexandre ArenalesDepartamento de Clinica e Cirurgia Veterinarias, Escola de Veterinaria, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Elizabeth R HughesDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX.
Luisella SpigaDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX.ORCID 0000-0002-4770-7156
Jiwoong KimDepartment of Clinical Science, Quantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas, TX.
Luis Sifuentes-DominguezDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX.
Petro StarokadomskyyDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX.ORCID 0000-0002-9848-9187
Purva GopalDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX.
Mariana X ByndlossDepartment of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN.
Renato L SantosDepartamento de Clinica e Cirurgia Veterinarias, Escola de Veterinaria, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Ezra BursteinDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX ezra.burstein@UTSouthwestern.edu.
Sebastian E WinterDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX sebastian.winter@UTSouthwestern.edu.ORCID 0000-0003-1532-9178
The University of Texas Southwestern Medical Center · USUniversidade Federal de Minas Gerais · BRMita Hospital · JPVanderbilt University Medical Center · US
Funding
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9MCentral metabolism of Salmonella in the inflamed gutR01AI118807 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Sebastian E Winter · 2015 to 2026
$5.3MRegulation of Nutrient Homeostasis by COMMD proteinsR01DK107733 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI DANIEL D BILLADEAU, Ezra Burstein · 2016 to 2026
$4.6MRole of the CCC complex in immune functionR01DK073639 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI BURSTEIN, EZRA · 2007 to 2020
$3.7MANTECEDANTS SEQUELAE OF CHILDHOOD ONSET DISEASEK12HD068369 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI SKAPEK, STEPHEN X · 2011 to 2020
$3.0MLactate metabolism during Salmonella infectionR21AI128151 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI WINTER, SEBASTIAN E · 2017 to 2018
$446kNIAID NIH HHS R01 AI118807NIAID NIH HHS R21 AI128151NICHD NIH HHS K12 HD068369NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK073639NIDDK NIH HHS R01 DK107733
Abstract
Chronic inflammation and gut microbiota dysbiosis, in particular the bloom of genotoxin-producing
Indexed as
Gastrointestinal MicrobiomeAnimalsColitisColorectal NeoplasmsDextran SulfateDysbiosisEscherichia coliInterleukin-10MiceNeoplasms, ExperimentalDextran SulfateIL10 protein, mouseInterleukin-10
Identifiers
What OpenQuestion holds
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LicenceCC BY-NC-SA
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.