Evidence map›Paper›PMID 31358495›Full record

ArticleThe British journal of general practice : the journal of the Royal College of General Practitioners2019

Measuring adherence to therapy in apparent treatment-resistant hypertension: a feasibility study in Irish primary care.

Peter Hayes, Monica Casey, Liam G Glynn, Gerard J Molloy, Hannah Durand, Eoin O'Brien, Eamon Dolan, Kishor Das, John Newell, David Finn and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The British journal of general practice : the journal of the Royal College of General Practitioners, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 24 citations in OpenAlex.

  1. Trial
  2. '4 Ss' for successful blood pressure control.Journal of hypertension · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Peter HayesGraduate Entry Medical School, University of Limerick, Limerick; Discipline of General Practice, National University of Ireland (NUI) Galway, Galway, Ireland.
Monica CaseyGraduate Entry Medical School, University of Limerick, Limerick, Ireland.
Liam G GlynnGraduate Entry Medical School, University of Limerick, Limerick, Ireland.
Gerard J MolloySchool of Psychology.
Hannah DurandSchool of Psychology.
Eoin O'BrienConway Institute, University College Dublin, Dublin, Ireland.
Eamon DolanDepartment of Medicine for the Elderly, Connolly Hospital, Blanchardstown, Dublin, Ireland.
Kishor DasSchool of Mathematics, Statistics and Applied Mathematics.
John NewellSchool of Mathematics, Statistics and Applied Mathematics.
David FinnDiscipline of Pharmacology and Therapeutics, School of Medicine, NUI Galway, Galway. Ireland.
Brendan HarhenDiscipline of Pharmacology and Therapeutics, School of Medicine, NUI Galway, Galway. Ireland.
Ann ConneelyDiscipline of Pharmacology and Therapeutics, School of Medicine, NUI Galway, Galway. Ireland.
Andrew W MurphyHealth Research Board Primary Care Clinical Trials Network; Discipline of General Practice, NUI Galway, Galway, Ireland.
University of Limerick · IEApplied Mathematics (United States) · USConnolly Hospital Blanchardstown · IEHealth Research Board · IEStatistics Finland · FIUniversity College Dublin · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundApparent treatment-resistant hypertension (aTRH) is defined as uncontrolled blood pressure (BP) in patients taking three or more antihypertensive medications. Some patients will have true treatment-resistant hypertension, some undiagnosed secondary hypertension, while others have pseudo-resistance. Pseudo-resistance occurs when non-adherence to medication, white-coat hypertension (WCH), lifestyle, and inadequate drug dosing are responsible for the poorly controlled BP.

aimTo examine the feasibility of establishing non-adherence to medication, for the first time in primary care, using mass spectrometry urine analysis. Operationalisation would be established by at least 50% of patients participating and 95% of samples being suitable for analysis. Clinical importance would be confirmed by >10% of patients being non-adherent. DESIGN AND

settingEligible patients with aTRH (

methodParticipants underwent mass spectrometry urine analysis to test adherence and ambulatory BP monitoring (ABPM) to examine WCH.

resultsOf the eligible patients invited, 52% (

conclusionIn patients with aTRH, the authors have established that it is feasible to examine non-adherence to medications using mass spectrometry urine analysis. One in four patients were found to be partially or fully non-adherent. Further research on how to incorporate this approach into individual patient consultations and its associated cost-effectiveness is now appropriate.

Indexed as

Blood Pressure Monitoring, AmbulatoryMedication AdherencePrimary Health CareAgedAged, 80 and overAntihypertensive AgentsFeasibility StudiesFemaleHumansHypertensionIrelandMaleMass SpectrometryMiddle AgedUrinalysisWhite Coat HypertensionAntihypertensive Agentshypertensionprimary carepseudo-resistancetreatment adherenceurinalysis

Identifiers

PMID31358495
PMCPMC6663096
OpenAlexW2965719189

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.