ArticleeLife2019
Cell-sized confinement controls generation and stability of a protein wave for spatiotemporal regulation in cells.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Cell-Size Confinement Drives Size-Dependent Scaling of Intracellular Reaction-Diffusion Waves for Robust Patterning.Small science · 2026Article
- Review
- Machine learning-aided design and screening of an emergent protein function in synthetic cells.Nature communications · 2024Article
- Multimolecular Competition Effect as a Modulator of Protein Localization and Biochemical Networks in Cell-Size Space.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Artificial cell system as a tool for investigating pattern formation mechanisms of intracellular reaction-diffusion waves.Biophysics and physicobiology · 2024Review
- The mechanism of MinD stability modulation by MinE in Min protein dynamics.PLoS computational biology · 2023Article
- In vitro assembly, positioning and contraction of a division ring in minimal cells.Nature communications · 2022Article
- Phospholipid synthesis inside phospholipid membrane vesicles.Communications biology · 2022Article
- Bridging scales in a multiscale pattern-forming system.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Mode selection mechanism in traveling and standing waves revealed by Min wave reconstituted in artificial cells.Science advances · 2022Article
- Trends and Outlooks in Synthetic Biology: A Special Issue for Celebrating 10 Years ofLife (Basel, Switzerland) · 2022Article
- Activation of a dilutedSTAR protocols · 2021Article
- System concentration shift as a regulator of transcription-translation system within liposomes.iScience · 2021Article
- Engineering spatiotemporal organization and dynamics in synthetic cells.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2021Review
- Pattern formation in reaction-diffusion system on membrane with mechanochemical feedback.Scientific reports · 2020Article
- Transcription and Translation in Cytomimetic Protocells Perform Most Efficiently at Distinct Macromolecular Crowding Conditions.ACS synthetic biology · 2020Article
- Delayed global feedback in the genesis and stability of spatiotemporal excitation patterns in paced biological excitable media.PLoS computational biology · 2020Article
- C-terminal eYFP fusion impairsOpen biology · 2020Article
- Self-organization Assay for Min Proteins ofBio-protocol · 2020Article
- Regulation of spatiotemporal patterning in artificial cells by a defined protein expression system.Chemical science · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The Min system, a system that determines the bacterial cell division plane, uses changes in the localization of proteins (a Min wave) that emerges by reaction-diffusion coupling. Although previous studies have shown that space sizes and boundaries modulate the shape and speed of Min waves, their effects on wave emergence were still elusive. Here, by using a microsized fully confined space to mimic live cells, we revealed that confinement changes the conditions for the emergence of Min waves. In the microsized space, an increased surface-to-volume ratio changed the localization efficiency of proteins on membranes, and therefore, suppression of the localization change was necessary for the stable generation of Min waves. Furthermore, we showed that the cell-sized space strictly limits parameters for wave emergence because confinement inhibits both the instability and excitability of the system. These results show that confinement of reaction-diffusion systems has the potential to control spatiotemporal patterns in live cells.
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Registered trials
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