Evidence map›Paper›PMID 31358027›Full record

ArticleJournal of orthopaedic surgery and research2019

TGF-β1 reduces the oxidative stress-induced autophagy and apoptosis in rat annulus fibrosus cells through the ERK signaling pathway.

Binbin Ni, Hao Shen, Wei Wang, Hua Lu, Leisheng Jiang

Open access · goldAbstract read
In one paragraph

Article in Journal of orthopaedic surgery and research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. The MnOGels (Basel, Switzerland) · 2024
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Oxidative medicine and cellular longevity · 2022
    Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Binbin NiDepartment of Orthopaedic Surgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, No. 1665 Kongjiang Road, Shanghai, 200092, China.
Hao ShenDepartment of Orthopaedic Surgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, No. 1665 Kongjiang Road, Shanghai, 200092, China.
Wei WangDepartment of Orthopaedic Surgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, No. 1665 Kongjiang Road, Shanghai, 200092, China.
Hua LuDepartment of Orthopaedic Surgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, No. 1665 Kongjiang Road, Shanghai, 200092, China. luhua@xinhuamed.com.cn.
Leisheng JiangDepartment of Orthopaedic Surgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, No. 1665 Kongjiang Road, Shanghai, 200092, China. jiangleisheng@xinhuamed.com.cn.
XinHua Hospital · CN

Funding

National Natural Science Foundation of China 81171757
6 · The paper itself

Abstract

backgroundThe aim of this study is to explore the effects of TGF-β1 on autophagy and apoptosis induced by exogenous hydrogen peroxide (H

methodsAF cells were isolated from rat lumbar discs and subjected to different concentrations of exogenous H

resultsH

conclusionsTGF-β1 reduced autophagy and apoptosis induced by exogenous H

Indexed as

AnimalsAnnulus FibrosusAutophagyCell SurvivalDose-Response Relationship, DrugHydrogen PeroxideMaleMAP Kinase Signaling SystemOxidative StressRatsRats, Sprague-DawleyTransforming Growth Factor beta1Hydrogen PeroxideTransforming Growth Factor beta1Annulus fibrosus cellsApoptosisAutophagyERKGlutathion peroxidase-1Hydrogen peroxideIntervertebral disc degeneration

Identifiers

PMID31358027
PMCPMC6664534
OpenAlexW2965365681

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.