Trial reportRadiation oncology (London, England)2019
Integrative assessment of brain and bone invasion in meningioma patients.
Trial report in Radiation oncology (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Seq-ing answers: exploring meningioma biology utilizing bulk RNA-seq-based reference landscapes.Frontiers in oncology · 2025Review
- Customised pre-operative cranioplasty to achieve maximal surgical resection of tumours with osseous involvement-a case series.Acta neurochirurgica · 2024Article
- The usefulness of [European journal of nuclear medicine and molecular imaging · 2023Article
- Next-generation PET/CT imaging in meningioma-first clinical experiences using the novel SSTR-targeting peptide [European journal of nuclear medicine and molecular imaging · 2023Article
- Nomogram based on MRI can preoperatively predict brain invasion in meningioma.Neurosurgical review · 2022Article
- The efficacy of preoperative MRI features in the diagnosis of meningioma WHO grade and brain invasion.Frontiers in oncology · 2022Article
- Bone Invasive Meningioma: Recent Advances and Therapeutic Perspectives.Frontiers in oncology · 2022Review
- Diagnosis of Invasive Meningioma Based on Brain-Tumor Interface Radiomics Features on Brain MR Images: A Multicenter Study.Frontiers in oncology · 2021Article
- CNS Invasion in Meningioma-How the Intraoperative Assessment Can Improve the Prognostic Evaluation of Tumor Recurrence.Cancers · 2020Article
- Extent of Hyperostotic Bone Resection in Convexity Meningioma to Achieve Pathologically Free Margins.Journal of Korean Neurosurgical Society · 2020Article
- A radiomics model for preoperative prediction of brain invasion in meningioma non-invasively based on MRI: A multicentre study.EBioMedicine · 2020Article
- Brain invasion as a diagnostic histological feature of atypical meningiomas: Not a standalone diagnostic criterion.Neuro-oncology advancesArticle
- Clinicopathological characteristics and prognostic factors of atypical meningiomas with bone invasion: a retrospective analysis of nine cases and literature review.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieReview
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundVarious prognostic factors have been suggested in meningioma patients including WHO grading, brain invasion and bone involvement, for instance. Brain invasion was included as an independent criterion in the recent WHO classification. However, assessability of brain or bone involvement is often limited or varies between histopathologic, operative and imaging reports. Objective of our study was to investigate prognostic values including brain and bone involvement according to different clinical approaches.
methodsA cohort of 111 patients was treated with primary, adjuvant or salvage irradiation between 2008 and 2017 using intensity-modulated radiotherapy. Positron-emission tomography (PET) was available for treatment planning in 81% of patients. Clinical data were extracted from the medical reports. Brain and bone involvement were stratified separately according to histopathologic, operative and imaging reports as well as judged in synopsis.
resultsWHO grade I tumours, lower estimated proliferation index, primary versus recurrence treatment and localization (i.e. skull base, optic nerve sheath) were beneficial prognostic factors for local control. Judgement of brain and bone invasion partly differed between diagnostic modalities. In synopsis, brain or bone invasion did not show a significant influence on local control rates.
conclusionsSeveral previously described prognostic factors could be reproduced. However, partly divergent histopathological, surgical and image-based judgements could be found in regard to brain and bone invasion and all methods imply limitations. Therefore, we suggest a particular, complemental synopsis judgement. In synopsis, brain or bone involvement did not coherently impair local control in our irradiated patients. This might be explained by elaborate radiation techniques and PET-based treatment planning.
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