ArticleJournal of orthopaedic surgery and research2019
Comparison of D-dimer with CRP and ESR for diagnosis of periprosthetic joint infection.
Article in Journal of orthopaedic surgery and research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07718386 (The Diagnosis Dilemma), which is not on this map. Cited by 29 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Diagnosis Dilemma: Efficacy of Serum ESR, CRP, Synovial Leucocyte Esterase Dipstick Test in the Diagnosis of Chronic Infection in Total Joint Arthroplasty.
Who cites it
29 citing papers in PubMed, 7 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Reliable Diagnostic Tests and Thresholds for Preoperative Diagnosis of Non-Inflammatory Arthritis Periprosthetic Joint Infection: A Meta-analysis and Systematic Review.Orthopaedic surgery · 2022Pooled it
- The accuracy of D-dimer in the diagnosis of periprosthetic infections: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2022Pooled it
- Role of D-dimer and Fibrinogen in the Diagnosis of Periprosthetic Joint Infection: A Systematic Review and Meta-Analysis.Orthopaedic surgery · 2021Pooled it
- Fibrinogen performs better than D-dimer for the diagnosis of periprosthetic joint infection: a meta-analysis of diagnostic trials.Journal of orthopaedic surgery and research · 2021Pooled it
- Diagnostic accuracy of D-dimer in periprosthetic joint infection: a diagnostic meta-analysis.Journal of orthopaedic surgery and research · 2020Pooled it
- Meta-analysis of serum and/or plasma D-dimer in the diagnosis of periprosthetic joint infection.Journal of orthopaedic surgery and research · 2020Pooled it
- D-dimer in the diagnosis of periprosthetic joint infection: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2020Pooled it
- Effect of vacuum sealing drainage on healing time and inflammation-related indicators in patients with soft tissue wounds.International wound journal · 2021Trial
- Early post-operative CRP is a better predictor of DAIR failure than pre-operative CRP in total knee PJI.Archives of orthopaedic and trauma surgery · 2026Article
- BMI-stratified nomograms to predict early SIRS-defined sepsis after flexible ureteroscopy.Frontiers in medicine · 2026Article
- Advances and Challenges in Orthopedic Implant-Associated Infections.Healthcare (Basel, Switzerland) · 2024Article
- The Challenge of Periprosthetic Joint Infection Diagnosis: From Current Methods to Emerging Biomarkers.International journal of molecular sciences · 2023Review
- Diagnosing Periprosthetic Joint Infection: a Scoping Review.Current reviews in musculoskeletal medicine · 2022Article
- The poor accuracy of D-dimer for the diagnosis of prosthetic joint infection but its potential usefulness in early postoperative infections following revision arthroplasty for aseptic loosening.BMC infectious diseases · 2022Article
- Total hip arthroplasty revision etiologies: a cross-sectional study in Isfahan, Iran.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2022Article
- Plasma levels of D-dimer and fibrin degradation product are unreliable for diagnosing periprosthetic joint infection in patients undergoing re-revision arthroplasty.Journal of orthopaedic surgery and research · 2021Article
- Limited value of serum neutrophil-to-lymphocyte ratio in the diagnosis of chronic periprosthetic joint infection.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2021Article
- Serum Inflammatory Biomarkers in the Diagnosis of Periprosthetic Joint Infections.Biomedicines · 2021Review
- Plasma fibrinogen, D-dimer, and fibrin degradation product as biomarkers of rheumatoid arthritis.Scientific reports · 2021Article
- Thromboelastography parameters in diagnosing periprosthetic joint infection and predicting reimplantation timing.BMC musculoskeletal disorders · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite the availability of several biomarkers, the diagnosis of periprosthetic joint infection (PJI) continues to be challenging. Serum D-dimer assessment is a widely available test that detects fibrinolytic activities and has been reported as an inflammatory biomarker. However, quite a few articles have reported the diagnostic efficiency of D-dimer for PJI.
methodsThis prospective study enrolled patients who had undergone total joint arthroplasty, were suspected of PJI, and also prepared for revision arthroplasty. PJI was defined using the Musculoskeletal Infection Society criteria. In all patients, serum D-dimer level, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) level were measured preoperatively. We then compared the diagnostic efficiency of these three biomarkers.
resultsThe median D-dimer level was significantly higher (p < 0.001) for the patients with PJI than for the patients with aseptic failure. With a sensitivity of 80.77% (95% CI, 65.62 to 95.92%) and a specificity of 79.63% (95% CI, 68.89 to 90.37%), the diagnostic efficiency of D-dimer did not outperform serum CRP (with a sensitivity of 84.61% and specificity of 64.81%) and ESR (with a sensitivity of 73.08% and specificity of 90.47%).
conclusionsSerum D-dimer as a marker for the diagnosis of PJI still requires more large-scale and detailed clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.