Evidence map›Paper›PMID 31357996›Full record

ArticleBMC veterinary research2019

Emergence of carriage of CTX-M-15 in faecal Escherichia coli in horses at an equine hospital in the UK; increasing prevalence over a decade (2008-2017).

C M Isgren, T Edwards, G L Pinchbeck, E Winward, E R Adams, P Norton, D Timofte, T W Maddox, P D Clegg, N J Williams

Open access · goldAbstract read
In one paragraph

Article in BMC veterinary research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
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  9. Article
  10. Horsing around:Antimicrobial agents and chemotherapy · 2023
    Article
  11. Article
  12. Extended-Spectrum Beta-Lactamases ProducingInfection and drug resistance · 2022
    Review
  13. Article
  14. Article
  15. Review
  16. Temporal, Spatial, and Genomic Analyses ofFrontiers in microbiology · 2021
    Article
  17. Article
  18. Review
  19. Article
  20. Extended-Spectrum β-lactamase-ProducingAnimals : an open access journal from MDPI · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

C M IsgrenInstitute of Infection and Global Health, University of Liverpool, Neston, England. cisgren@liv.ac.uk.
T EdwardsResearch Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Liverpool, England.
G L PinchbeckInstitute of Infection and Global Health, University of Liverpool, Neston, England.
E WinwardResearch Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Liverpool, England.
E R AdamsResearch Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Liverpool, England.
P NortonResearch Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Liverpool, England.
D TimofteInstitute of Infection and Global Health, University of Liverpool, Neston, England.
T W MaddoxDepartment of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, England.
P D CleggDepartment of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, England.
N J WilliamsInstitute of Infection and Global Health, University of Liverpool, Neston, England.
University of Liverpool · GBLiverpool School of Tropical Medicine · GB

Funding

Medical Research Council MC_PC_15040Medical Research Council MC_PC_16052The Horse Trust G2015
6 · The paper itself

Abstract

backgroundThis study investigated changes over time in the epidemiology of extended-spectrum β-lactamase (ESBL) producing Escherichia coli within a single equine referral hospital in the UK. Faecal samples were collected from hospitalised horses in 2008 and 2017, processed using selective media and standard susceptibility laboratory methods. A novel real-time PCR with high resolution melt analysis was used to distinguish bla

resultsIn 2008, 457 faecal samples from 103 horses were collected, with ESBL-producing E. coli identified in 131 samples (28.7, 95% CI 24.6-33.1). In 2017, 314 faecal samples were collected from 74 horses with ESBL-producing E. coli identified in 157 samples (50.0, 95% CI 44.5-55.5). There were 135 and 187 non-duplicate ESBL-producing isolates from 2008 and 2017, respectively. In 2008, 12.6% of isolates belonged to CTX-M-1 group, all carrying bla

conclusionsThe real-time PCR proved a reliable and high throughput method to distinguish between bla

Indexed as

AnimalsAnti-Bacterial Agentsbeta-LactamasesDrug Resistance, BacterialEscherichia coliEscherichia coli InfectionsFecesHorse DiseasesHorsesHospitals, AnimalPrevalenceUnited KingdomAnti-Bacterial Agentsbeta-LactamasesCTX-M-1 groupESBL-producing E. coliHigh resolution meltMelt curve analysisMultidrug resistanceReal time PCR

Identifiers

PMID31357996
PMCPMC6664770
OpenAlexW2964952611

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.