ArticleBMC infectious diseases2019
Clinical characteristics and outcomes during a severe influenza season in China during 2017-2018.
Article in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effect of age on the incidence of COVID-19 complications: a systematic review and meta-analysis.Systematic reviews · 2021Pooled it
- A Human Mobility-Based Modeling Study of Influenza Vaccination Strategies Across Socioeconomically Disparate Regions in China.Vaccines · 2026Article
- Molecular characterisation of influenza B virus from the 2017/18 season in primary models of the human lung reveals improved adaptation to the lower respiratory tract.Emerging microbes & infections · 2024Article
- Clinical characteristics of outpatients with influenza-B-associated pneumonia and molecular evolution of influenza B virus in Beijing, China, during the 2021-2022 influenza season.Archives of virology · 2024Article
- Clinical characteristics and assessment of risk factors in patients with influenza A-induced severe pneumonia after the prevalence of SARS-CoV-2.Open medicine (Warsaw, Poland) · 2024Article
- Spatiotemporal patterns of lung disease in China before 2019: A brief analysis of two nationally representative surveys.PloS one · 2022Article
- Behavior of hospitalized severe influenza cases according to the outcome variable in Catalonia, Spain, during the 2017-2018 season.Scientific reports · 2021Observational
- Pathogenicity and transmissibility assessment of two strains of human influenza virus isolated in China in 2018.The Journal of international medical research · 2021Article
- Article
- Impact of early neuraminidase inhibitor treatment on clinical outcomes in patients with influenza B-related pneumonia: a multicenter cohort study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Article
- Severity and outcomes of influenza-related pneumonia in type A and B strains in China, 2013-2019.Infectious diseases of poverty · 2020Article
- Robust induction of interferon and interferon-stimulated gene expression by influenza B/Yamagata lineage virus infection of A549 cells.PloS one · 2020Article
- Whole-genome sequencing reveals origin and evolution of influenza A(H1N1)pdm09 viruses in Lincang, China, from 2014 to 2018.PloS one · 2020Article
- The Phylodynamics of Seasonal Influenza A/H1N1pdm Virus in China Between 2009 and 2019.Frontiers in microbiology · 2020Article
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11 authors.
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Abstract
backgroundA severe seasonal influenza epidemic was observed during 2017-2018 in China, prompting questions on clinical characteristics and outcomes of severe cases with influenza.
methodsWe retrospectively collected clinical data and outcomes of laboratory-confirmed hospitalized patients (severe to critical) during Jan-2011 to Feb-2018 from five hospitals, followed by a systematic analysis of cases from 2017 to 2018 (n = 289) and all previous epidemics during 2011-2017 (n = 169).
resultsIn-hospital fatality was over 5-folds higher during the 2017-2018 (p < 0.01) in which 19 patients died (6.6%), whereas only 2 mortalities (1.2%) were observed during 2011-2017. Of the 289 hospitalized in 2017-2018, 153 were confirmed with influenza B virus, 110 with A/H1N1pdm09, and 26 A/H3N2, whereas A/H1N1pdm09 was the predominant cause of hospitalization in previous seasons combined (45%). Fatal cases in 2017-2018 were exclusively associated with either influenza B or A/H1N1pdm09. Our results show that a significant lower proportion of patients aged 14 or greater were treated with oseltamivir, during the 2017-2018 epidemic, and exhibited higher levels of clinical severity.
conclusionsIn-hospital fatality rate might be significantly higher in the 2017-2018 season in China. A sufficient supply of oseltamivir and antiviral therapy within 48 h from onset could reduce fatality rates.
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