Evidence map›Paper›PMID 31357742›Full record

ArticleSensors (Basel, Switzerland)2019

How to Select Balance Measures Sensitive to Parkinson's Disease from Body-Worn Inertial Sensors-Separating the Trees from the Forest.

Naoya Hasegawa, Vrutangkumar V Shah, Patricia Carlson-Kuhta, John G Nutt, Fay B Horak, Martina Mancini

Open access · goldAbstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 3 pooled it
19.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 73 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Naoya HasegawaDepartment of Neurology, Oregon Health & Science University, Portland, OR 97239-3098, USA.ORCID 0000-0002-0791-8469
Vrutangkumar V ShahDepartment of Neurology, Oregon Health & Science University, Portland, OR 97239-3098, USA.
Patricia Carlson-KuhtaDepartment of Neurology, Oregon Health & Science University, Portland, OR 97239-3098, USA.
John G NuttDepartment of Neurology, Oregon Health & Science University, Portland, OR 97239-3098, USA.
Fay B HorakDepartment of Neurology, Oregon Health & Science University, Portland, OR 97239-3098, USA.
Martina ManciniDepartment of Neurology, Oregon Health & Science University, Portland, OR 97239-3098, USA. mancinim@ohsu.edu.
Oregon Health & Science University · US

Funding

PERIPHERAL AND CENTRAL POSTURAL DISORDERS IN THE ELDERLYR01AG006457 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI HORAK, FAY BAHLING · 1986 to 2018
$5.2M
Body-Worn Sensors to Characterize & Treat Freezing of Gait in Parkinson's DiseaseR00HD078492 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI MANCINI, MARTINA · 2016 to 2018
$701k
Department of Veterans Affairs Merit Award 5I01RX001075Foundation for the National Institutes of Health R01AG006457NIA NIH HHS R01 AG006457NICHD NIH HHS R00 HD078492RRD VA I01 RX001075
6 · The paper itself

Abstract

This study aimed to determine the most sensitive objective measures of balance dysfunction that differ between people with Parkinson's Disease (PD) and healthy controls. One-hundred and forty-four people with PD and 79 age-matched healthy controls wore eight inertial sensors while performing tasks to measure five domains of balance: standing posture (Sway), anticipatory postural adjustments (APAs), automatic postural responses (APRs), dynamic posture (Gait) and limits of stability (LOS). To reduce the initial 93 measures, we selected uncorrelated measures that were most sensitive to PD. After applying a threshold on the Standardized Mean Difference between PD and healthy controls, 44 measures remained; and after reducing highly correlated measures, 24 measures remained. The four most sensitive measures were from APAs and Gait domains. The random forest with 10-fold cross-validation on the remaining measures (n = 24) showed an accuracy to separate PD from healthy controls of 82.4%-identical to result for all measures. Measures from the most sensitive domains, APAs and Gait, were significantly correlated with the severity of disease and with patient-related outcomes. This method greatly reduced the objective measures of balance to the most sensitive for PD, while still capturing four of the five domains of balance.

Indexed as

Wearable Electronic DevicesAgedAged, 80 and overFemaleGaitHumansMaleMiddle AgedParkinson DiseasePostural BalanceSeverity of Illness IndexStanding Positionbalance dysfunctionfeature selectioninertial measurement unitobjective measuresParkinson’s diseasewearable technology

Identifiers

PMID31357742
PMCPMC6696209
OpenAlexW2965549584

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.