ReviewInternational journal of molecular sciences2019
Role of the Monocyte-Macrophage System in Normal Pregnancy and Preeclampsia.
Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- Preeclampsia Genomic Susceptibility Factors in Populations of African Ancestry: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2026Pooled it
- Endothelial cells exposed to preeclamptic placental macrophages show increased oxidative stress and impaired angiogenesis in vitro.Pregnancy hypertension · 2026Article
- Multi-omics biomarkers in endometrial receptivity: from mechanisms to clinical translation.Journal of translational medicine · 2026Review
- The Ghrelin/GHSR-1a Axis Attenuates Preeclampsia-like Features with Decidual Macrophage Reprogramming and Improved Placental Remodeling.Biomolecules · 2026Article
- Systemic Immune-Inflammation Index as a Predictive Biomarker for Pre-Eclampsia.Journal of clinical medicine · 2026Review
- Maternal opioid use disorder and hepatitis C infection in pregnancy reshape the peripheral immune landscape at term.EBioMedicine · 2026Article
- The signature of pyroptosis-related gene diagnosis and immune microenvironment in preeclampsia.BMC pregnancy and childbirth · 2026Article
- Regulation of PI3K/Akt in preeclampsia: an examination of its pathological role and therapeutic potential.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Article
- Inflammation at the maternal-fetal interface: a perspective on interacting risk factors for preterm birth in sub-Saharan African women living with HIV.Frontiers in immunology · 2026Review
- Pregnancy-associated metabolic adaptations in circulating monocytes and macrophages favor clearance functions.Frontiers in immunology · 2026Article
- Multivariate model predicts immune imbalance in recurrent pregnancy loss and recurrent implantation failure.Reproduction & fertility · 2026Article
- Immune Cells in Preeclampsia.International journal of molecular sciences · 2025Review
- Monocytes at the crossroads of inflammation and labor: biomarker potential in prolonged deliveries - a narrative review.Annals of medicine and surgery (2012) · 2025Article
- Autophagy in PE: Dispute, Role and Potential Target.Cell proliferation · 2025Review
- Role of monocytes in the pathogenesis of antiphospholipid syndrome and potential therapeutic targets (Review).Molecular medicine reports · 2025Review
- Placental mesenchymal stem cell exosomes drive macrophage M2 polarizationEuropean journal of histochemistry : EJH · 2025Article
- Single-Cell Transcriptome and RNA Sequencing Reveal Immune-Related Markers of Preeclampsia.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Apoptotic vesicles of mesenchymal stem cells promote M2 polarization and alleviate early-onset preeclampsia via miR-191-5p.Stem cell research & therapy · 2025Article
- Cross one single body 49 tissues single-cell transcriptome reveals detailed macrophage heterogeneity during pig pregnancy.Frontiers in immunology · 2025Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The proper functioning of the monocyte-macrophage system, an important unit of innate immunity, ensures the normal course of pregnancy. In this review, we present the current data on the origin of the monocyte-macrophage system and its functioning in the female reproductive system during the ovarian cycle, and over the course of both normal and complicated pregnancy. Preeclampsia is a crucial gestation disorder characterized by pronounced inflammation in the maternal body that affects the work of the monocyte-macrophage system. The effects of inflammation at preeclampsia manifest in changes in monocyte counts and their subset composition, and changes in placental macrophage counts and their polarization. Here we summarize the recent data on this issue for both the maternal organism and the fetus. The influence of estrogen on macrophages and their altered levels in preeclampsia are also discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.