Evidence map›Paper›PMID 31357692›Full record

ReviewCells2019

Mesenchymal Stem Cell Migration and Tissue Repair.

Xiaorong Fu, Ge Liu, Alexander Halim, Yang Ju, Qing Luo, And Guanbin Song

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05582226 (A Randomized, Single Blinded Study of the Augmentation of Anterior Cruciate Ligament Reconstruction Using Stump-Derived Mesenchymal Stem Cells Versus Standard of Care Anterior Cruciate Ligament Reconstruction), which is not on this map. Cited by 558 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
558citing papers in PubMed, 3 pooled it
62.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05582226 naunknown statusnot on this mapstarted 2022, after this paper: background citation

A Randomized, Single Blinded Study of the Augmentation of Anterior Cruciate Ligament Reconstruction Using Stump-Derived Mesenchymal Stem Cells Versus Standard of Care Anterior Cruciate Ligament Reconstruction

TypeinterventionalSponsorAndrews Research & Education FoundationRan2022 to 2023Enrolled50ConditionsACL TearArmsACL reconstruction, Mesenchymal stem cell implantation
3 · Its place in the literature

Who cites it

558 citing papers in PubMed, 3 syntheses or guidelines pooled it, 1,059 citations in OpenAlex.

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498 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Xiaorong FuCollege of Bioengineering, Chongqing University, Key Laboratory of Biorheological Science and Technology, Ministry of Education, Chongqing 400030, China.
Ge LiuCollege of Bioengineering, Chongqing University, Key Laboratory of Biorheological Science and Technology, Ministry of Education, Chongqing 400030, China.
Alexander HalimCollege of Bioengineering, Chongqing University, Key Laboratory of Biorheological Science and Technology, Ministry of Education, Chongqing 400030, China.
Yang JuDepartment of Mechanical Science and Engineering, Nagoya University, Nagoya 464-8603, Japan.
Qing LuoCollege of Bioengineering, Chongqing University, Key Laboratory of Biorheological Science and Technology, Ministry of Education, Chongqing 400030, China.
And Guanbin SongCollege of Bioengineering, Chongqing University, Key Laboratory of Biorheological Science and Technology, Ministry of Education, Chongqing 400030, China. song9973@163.com.
Chongqing University · CNNagoya University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) are multilineage cells with the ability to self-renew and differentiate into a variety of cell types, which play key roles in tissue healing and regenerative medicine. Bone marrow-derived mesenchymal stem cells (BMSCs) are the most frequently used stem cells in cell therapy and tissue engineering. However, it is prerequisite for BMSCs to mobilize from bone marrow and migrate into injured tissues during the healing process, through peripheral circulation. The migration of BMSCs is regulated by mechanical and chemical factors in this trafficking process. In this paper, we review the effects of several main regulatory factors on BMSC migration and its underlying mechanism; discuss two critical roles of BMSCs-namely, directed differentiation and the paracrine function-in tissue repair; and provide insight into the relationship between BMSC migration and tissue repair, which may provide a better guide for clinical applications in tissue repair through the efficient regulation of BMSC migration.

Indexed as

Cell MovementWound HealingAnimalsCell DifferentiationHumansMesenchymal Stem CellsRegenerationTranscription FactorsTranscription Factorsdifferentiationmechanochemical regulationmesenchymal stem cellsmigrationparacrinetissue repair

Identifiers

PMID31357692
PMCPMC6721499
OpenAlexW2965698862

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.