Evidence map›Paper›PMID 31357624›Full record

ArticleInternational journal of molecular sciences2019

Interrogating the Essential Bacterial Cell Division Protein FtsQ with Fragments Using Target Immobilized NMR Screening (TINS).

Marjolein Glas, Eiso Ab, Johan Hollander, Gregg Siegal, Joen Luirink, Iwan de Esch

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. In Silico Druggability Assessment ofAntibiotics (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Review
  4. NMR in target driven drug discovery: why not?Journal of biomolecular NMR · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marjolein GlasDivision of Molecular Microbiology, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS),Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.ORCID 0000-0001-9888-7604
Eiso AbZobio BV, 2333 CH Leiden, The Netherlands.ORCID 0000-0002-5758-0435
Johan HollanderZobio BV, 2333 CH Leiden, The Netherlands.
Gregg SiegalZobio BV, 2333 CH Leiden, The Netherlands.
Joen LuirinkDivision of Molecular Microbiology, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS),Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.
Iwan de EschDivision of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS),Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands. i.de.esch@vu.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The divisome is a large protein complex that regulates bacterial cell division and therefore represents an attractive target for novel antibacterial drugs. In this study, we report on the ligandability of FtsQ, which is considered a key component of the divisome. For this, the soluble periplasmic domain of

Indexed as

Nuclear Magnetic Resonance, BiomolecularCell DivisionEscherichia coli ProteinsMembrane ProteinsStructure-Activity RelationshipEscherichia coli ProteinsFtsQ protein, E coliMembrane Proteinsantibacterialsbacterial cell divisiondivisomeEscherichia colifragment screeningFtsQNMRTINS

Identifiers

PMID31357624
PMCPMC6695665

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.