ArticleJournal of clinical medicine2019
Investigating Stress Response during Vaginal Delivery and Elective Cesarean Section through Assessment of Levels of Cortisol, Interleukin 6 (IL-6), Growth Hormone (GH) and Insulin-Like Growth Factor 1 (IGF-1).
Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05840406 (Effect of a Transversus Abdominis Plane Block on Operative Wound Healing, Stress, and Immune Response After a Cesarean Delivery), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of a Transversus Abdominis Plane Block on Operative Wound Healing, Stress, and Immune Response After a Cesarean Delivery
Who cites it
17 citing papers in PubMed.
- Effects of an Informational Video About Anesthesia on Pre- and Post-Elective Cesarean Section Anxiety and Recovery: A Randomized Controlled Trial.Medical science monitor : international medical journal of experimental and clinical research · 2020Trial
- Macular development in preterm twins with and without retinopathy of prematurity: an OCT angiography study from the Shenzhen prematurity eye study.European journal of medical research · 2026Article
- The Predictive Value of Umbilical Cord Interleukin-6: Implications for Neonatal Care-A Narrative Review of Current Evidence and Future Perspectives.Life (Basel, Switzerland) · 2025Review
- Cord blood levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 correlate with perinatal brain development in fetal congenital heart disease.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025Observational
- Systemic Inflammatory Indices in Transient Tachypnea of the Newborn: A Retrospective Case-Control Study.Children (Basel, Switzerland) · 2025Article
- A microbial symphony: a literature review of the factors that orchestrate the colonization dynamics of the human colonic microbiome during infancy and implications for future health.Microbiome research reports · 2025Review
- Article
- Stress Response Assessment between First and Second Elective Caesarean Sections by Comparing Cortisol Levels.Acta medica academica · 2023Observational
- Human Milk Oligosaccharides and Bacterial Profile Modulate Infant Body Composition during Exclusive Breastfeeding.International journal of molecular sciences · 2022Article
- Relationship between Physical Activity and the Metabolic, Inflammatory Axis in Pregnant Participants.International journal of environmental research and public health · 2021Article
- Correlation of perilipin 2 and lipid metabolism in elective cesarean section and vaginal delivery: a prospective study with oxidative and apoptotic pathways.Molecular biology reports · 2021Article
- Reduced Number and Activity of Circulating Endothelial Progenitor Cells in Acute Aortic Dissection and Its Relationship With IL-6 and IL-17.Frontiers in cardiovascular medicine · 2021Article
- Pregnancy with COVID-19: Management considerations for care of severe and critically ill cases.American journal of reproductive immunology (New York, N.Y. : 1989) · 2020Review
- Maternal Microbiota, Cortisol Concentration, and Post-Partum Weight Recovery are Dependent on Mode of Delivery.Nutrients · 2020Article
- Article
- S100-Alarmins Are Essential Pilots of Postnatal Innate Immune Adaptation.Frontiers in immunology · 2020Review
- Caesarean section delivery and childhood obesity in a British longitudinal cohort study.PloS one · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHow do stress related phenomena during labor differ between vaginal delivery (VD) and elective cesarean section (CS), remains of heightened interest. The purpose of this study is to investigate discrepancies regarding the stress response during VD and CS.
methodsCortisol, interleukin 6 (IL-6), growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels from parturients' peripheral blood were evaluated on three time-points, namely during the first stage of labor (TP1), two hours post labor (TP2) and 48 h post labor (TP3). Levels were also evaluated from the umbilical cord blood. A total of 50 women were enrolled in this prospective cohort study, with 24 and 26 subjected to CS and VD, respectively.
resultsNo statistically significant differences were observed between the two groups at TP1. Only GH levels presented the same pattern during the three time-points among both groups. In the umbilical cord blood, the CS group presented statistically significant higher IGF-1 and GH levels. In the umbilical cord blood, IGF-1 and GH levels were positively correlated, while GH and cortisol levels were negatively correlated.
conclusionCS is a less stressful procedure than VD and is further associated with less intense inflammation, albeit with a longer inflammatory response period. Labor physiology during CS differs considerably regarding respective observations during VD. This merits extensive investigation in order to decipher these data for optimal clinical practice and guidelines.
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