ArticleMolecules (Basel, Switzerland)2019
Prediction of Transformation Products of Monensin by Electrochemistry Compared to Microsomal Assay and Hydrolysis.
Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 6 citations in OpenAlex.
- Working with technical purity: simulation of red tattoo pigment metabolism by online-liquid chromatography-electrochemistry-mass spectrometry.Analytical and bioanalytical chemistry · 2026Article
- Oxidation and Reduction of Hydrazones-Risk Factors Related to the Manufacture and Stability of the Drugs.International journal of molecular sciences · 2025Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
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Abstract
The knowledge of transformation pathways and identification of transformation products (TPs) of veterinary drugs is important for animal health, food, and environmental matters. The active agent Monensin (MON) belongs to the ionophore antibiotics and is widely used as a veterinary drug against coccidiosis in broiler farming. However, no electrochemically (EC) generated TPs of MON have been described so far. In this study, the online coupling of EC and mass spectrometry (MS) was used for the generation of oxidative TPs. EC-conditions were optimized with respect to working electrode material, solvent, modifier, and potential polarity. Subsequent LC/HRMS (liquid chromatography/high resolution mass spectrometry) and MS/MS experiments were performed to identify the structures of derived TPs by a suspected target analysis. The obtained EC-results were compared to TPs observed in metabolism tests with microsomes and hydrolysis experiments of MON. Five previously undescribed TPs of MON were identified in our EC/MS based study and one TP, which was already known from literature and found by a microsomal assay, could be confirmed. Two and three further TPs were found as products in microsomal tests and following hydrolysis, respectively. We found decarboxylation,
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