Evidence map›Paper›PMID 31357588›Full record

ArticleMarine drugs2019

Eckol Inhibits Particulate Matter 2.5-Induced Skin Keratinocyte Damage via MAPK Signaling Pathway.

Ao Xuan Zhen, Yu Jae Hyun, Mei Jing Piao, Pincha Devage Sameera Madushan Fernando, Kyoung Ah Kang, Mee Jung Ahn, Joo Mi Yi, Hee Kyoung Kang, Young Sang Koh, Nam Ho Lee and 1 more

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Protective Effects ofCurrent issues in molecular biology · 2025
    Article
  6. Air Pollution and Skin Diseases.Annals of dermatology · 2025
    Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Antioxidant, Anti-Inflammation and Antiaging Activities ofAntioxidants (Basel, Switzerland) · 2022
    Article
  18. Staphylococcus epidermidis WF2R11 Suppresses PMProbiotics and antimicrobial proteins · 2022
    Article
  19. Clionasterol-Rich Fraction ofAntioxidants (Basel, Switzerland) · 2022
    Article
  20. Hesperidin Exhibits Protective Effects against PMMolecules (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Ao Xuan ZhenSchool of Medicine, Jeju National University, Jeju 63243, Korea.
Yu Jae HyunSchool of Medicine, Jeju National University, Jeju 63243, Korea.
Mei Jing PiaoSchool of Medicine, Jeju National University, Jeju 63243, Korea.
Pincha Devage Sameera Madushan FernandoSchool of Medicine, Jeju National University, Jeju 63243, Korea.
Kyoung Ah KangSchool of Medicine, Jeju National University, Jeju 63243, Korea.
Mee Jung AhnLaboratory of Veterinary Anatomy, College of Veterinary Medicine, Jeju National University, Jeju 63243, Korea.
Joo Mi YiDepartment of Microbiology and Immunology, College of Medicine, Inje University, Busan 47392, Korea.
Hee Kyoung KangSchool of Medicine, Jeju National University, Jeju 63243, Korea.
Young Sang KohSchool of Medicine, Jeju National University, Jeju 63243, Korea.
Nam Ho LeeDepartment of Chemistry and Cosmetics, College of Natural Sciences, Jeju National University, Jeju 63243, Korea.
Jin Won HyunSchool of Medicine, Jeju National University, Jeju 63243, Korea. jinwonh@jejunu.ac.kr.ORCID 0000-0002-3403-3762
Jeju National University · KRInje University · KR

Funding

National Research Foundation of Korea NRF-2017R1A4A1014512
6 · The paper itself

Abstract

Toxicity of particulate matter (PM) towards the epidermis has been well established in many epidemiological studies. It is manifested in cancer, aging, and skin damage. In this study, we aimed to show the mechanism underlying the protective effects of eckol, a phlorotannin isolated from brown seaweed, on human HaCaT keratinocytes against PM

Indexed as

ApoptosisCell LineDioxinsHumansKeratinocytesMAP Kinase Signaling SystemMitochondriaMitochondrial DiseasesParticulate MatterReactive Oxygen SpeciesSeaweedSignal TransductionSkinDioxinseckolParticulate MatterReactive Oxygen Specieskeratinocytesparticulate matterphlorotanninreactive oxygen species

Identifiers

PMID31357588
PMCPMC6723658
OpenAlexW2965545342

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.