Evidence map›Paper›PMID 31357570›Full record

ArticlePolymers2019

Ultrasound-Assisted Encapsulation of Sacha Inchi (

Mariela Elgegren, Suyeon Kim, Diego Cordova, Carla Silva, Jennifer Noro, Artur Cavaco-Paulo, Javier Nakamatsu

Open access · goldAbstract read
In one paragraph

Article in Polymers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Mariela ElgegrenDepartment of Science, Chemistry Division, Pontificia Universidad Católica del Perú PUCP, Av. Universitaria 1801, Lima 32, Peru.
Suyeon KimDepartment of Engineering, Pontificia Universidad Católica del Perú PUCP, Av. Universitaria 1801, Lima 32, Peru. skim@pucp.pe.
Diego CordovaDepartment of Science, Chemistry Division, Pontificia Universidad Católica del Perú PUCP, Av. Universitaria 1801, Lima 32, Peru.
Carla SilvaCentre of Biological Engineering, University of Minho, Campus De Gualtar, 4710-057 Braga, Portugal.
Jennifer NoroCentre of Biological Engineering, University of Minho, Campus De Gualtar, 4710-057 Braga, Portugal.
Artur Cavaco-PauloCentre of Biological Engineering, University of Minho, Campus De Gualtar, 4710-057 Braga, Portugal.ORCID 0000-0001-7204-2064
Javier NakamatsuDepartment of Science, Chemistry Division, Pontificia Universidad Católica del Perú PUCP, Av. Universitaria 1801, Lima 32, Peru.ORCID 0000-0001-7721-7716
Pontificia Universidad Católica del Perú · PEUniversity of Minho · PT

Funding

Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica 151-2017-FONDECYT
6 · The paper itself

Abstract

Sacha inchi oil is rich in essential and non-essential fatty acids and other types of bioactive agents like tocopherols and polyphenolic compounds, which are very well-known antioxidants. In this study, the encapsulation of sacha inchi oil in alginate (AL) and chitosan (CS) nanoparticles was achieved with the assistance of high-intensity ultrasound. Nanoemulsion is the most effective delivery and high stability system for lipophilic bioactive agents. Chitosan and surfactant concentrations were varied to study their effect on particle formulations. Size, zeta-potential, polydispersity, and stability of particles were determined in time to optimize the preparation conditions. Sacha inchi oil encapsulated in AL-CS nanoparticles showed a higher loading efficiency and stability for short and long periods compared with other vegetable oils such as olive and soybean. Also, because of the types of tocopherols present in sacha inchi oil (γ- and δ-tocopherols), a much higher antioxidant activity (95% of radical reduction in 15 min) was found in comparison with nanocapsules with olive oil, which contain α-tocopherols. The particles showed high efficiency of protein loading at high concentration of bovine serum albumin (BSA) and a low rate of leaching profiles in various testing media like simulated gastric and intestinal fluids with/without enzymes, that is, pepsin 0.1% (

Indexed as

antioxidantnanoemulsionNile redprotein loadingsacha inchitocopherols

Identifiers

PMID31357570
PMCPMC6723186
OpenAlexW2965991976

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.