Observational studyInternational journal of environmental research and public health2019
Substantial and Sustained Improvements in Blood Pressure, Weight and Lipid Profiles from a Carbohydrate Restricted Diet: An Observational Study of Insulin Resistant Patients in Primary Care.
Observational study in International journal of environmental research and public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exploring Non-pharmacological Hypertension Management: DASH, Paleolithic, and Ketogenic Diet Comparisons: A Systematic Review.Current hypertension reviews · 2026Pooled it
- Biological Pathways of Strength Preservation During Calorie Restriction-Induced Weight Loss Among Adults Without Obesity.Obesity (Silver Spring, Md.) · 2026Trial
- The Relationship Between a Low-Carbohydrate Diet and the Prevalence of Diabetic Kidney Disease in Patients With Type 2 Diabetes: A Cross-Sectional Study.Food science & nutrition · 2026Article
- Biological Mechanisms of Strength Preservation During Calorie Restriction-Induced Weight Loss Among Young- to Middle-Aged Adults without Obesity.bioRxiv : the preprint server for biology · 2026Article
- Design and rationale for MICROFIT (Microvascular Coronary Rehabilitation For Improving Treatment)-a feasibility randomized trial of intensive lifestyle rehabilitation for symptomatic coronary microvascular dysfunction.Frontiers in cardiovascular medicine · 2026Article
- Associations of low carbohydrate diet score with blood pressure levels and hypertension among middle-aged Japanese: the Toon Health Study.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Review
- Ketogenic Diet Intervention for Obesity Weight-Loss- A Narrative Review, Challenges, and Open Questions.Current nutrition reports · 2025Review
- Continuous Glucose Monitors and Programmed Shared Medical Appointments in Managing Type 2 Diabetes Mellitus Among First Nation Women in Australia: A Co-Designed Feasibility Study.American journal of lifestyle medicine · 2025Article
- Integrating the management of ultra-processed food addiction into type 2 diabetes care: a clinical response to De Silva et al, (2025) and practical recommendations for practitioners.Frontiers in psychiatry · 2025Article
- Dietary Guidelines Post Kidney Transplant: Is This the Missing Link in Recovery and Graft Survival?Transplant international : official journal of the European Society for Organ Transplantation · 2025Review
- The case for a ketogenic diet in the management of kidney disease.BMJ open diabetes research & care · 2024Review
- Dietary Influence on Drug Efficacy: A Comprehensive Review of Ketogenic Diet-Pharmacotherapy Interactions.Nutrients · 2024Review
- Opinion: Are mental health benefits of the ketogenic diet accompanied by an increased risk of cardiovascular disease?Frontiers in nutrition · 2024Article
- 'Super Rehab': can we achieve coronary artery disease regression? A feasibility study protocol.BMJ open · 2023Article
- Insulin Resistance and Hypertension: Mechanisms Involved and Modifying Factors for Effective Glucose Control.Biomedicines · 2023Review
- Associations between Dietary Patterns and Metabolic Syndrome: Findings of the Korean National Health and Nutrition Examination Survey.Nutrients · 2023Article
- Article
- What predicts drug-free type 2 diabetes remission? Insights from an 8-year general practice service evaluation of a lower carbohydrate diet with weight loss.BMJ nutrition, prevention & health · 2023Article
- From Young to Older, the 4 Phases Method Is Efficient in Promoting Quick Weight, BMI, and Waist Circumference Reductions.Healthcare (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypertension is the second biggest known global risk factor for disease after poor diet; perhaps lifestyle interventions are underutilized? In a previous small pilot study, it was found that a low carbohydrate diet was associated with significant improvements in blood pressure, weight, 'deprescribing' of medications and lipid profiles. We were interested to investigate if these results would be replicated in a larger study based in 'real world' GP practice. 154 patients with type 2 diabetes or impaired glucose tolerance were recruited into an observational cohort study in primary care. The effects of a low carbohydrate diet sustained for an average of two years (interquartile range 10-32 months) on cardiovascular risk factors were examined. Results demonstrate significant and substantial reductions in blood pressure (mean reduction of systolic BP 10.9 mmHg (interquartile range 0-22 mmHg) (
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Registered trials
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