Evidence map›Paper›PMID 31357468›Full record

ArticleBrain sciences2019

Using Dual-Site Transcranial Magnetic Stimulation to Probe Connectivity between the Dorsolateral Prefrontal Cortex and Ipsilateral Primary Motor Cortex in Humans.

Matt J N Brown, Elana R Goldenkoff, Robert Chen, Carolyn Gunraj, Michael Vesia

Abstract read
In one paragraph

Article in Brain sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Matt J N BrownDepartment of Kinesiology and Health Science, California State University Sacramento, Sacramento, California, CA 95819-6073, USA.
Elana R GoldenkoffBrain and Behavior Laboratory, School of Kinesiology University of Michigan, Ann Arbor, Michigan, MI 48109-2214, USA.
Robert ChenDivision of Brain, Imaging and Behaviour-Systems Neuroscience, Krembil Brain Institute, Toronto, ON M5T 2S8, Canada.
Carolyn GunrajDivision of Brain, Imaging and Behaviour-Systems Neuroscience, Krembil Brain Institute, Toronto, ON M5T 2S8, Canada.
Michael VesiaBrain and Behavior Laboratory, School of Kinesiology University of Michigan, Ann Arbor, Michigan, MI 48109-2214, USA. mvesia@umich.edu.ORCID 0000-0003-3609-4902

Funding

Canadian Institutes of Health Research FDN 154292Canadian Institutes of Health Research PDF 338973Parkinson's Canada 2016-974
6 · The paper itself

Abstract

Dual-site transcranial magnetic stimulation to the primary motor cortex (M1) and dorsolateral prefrontal cortex (DLPFC) can be used to probe functional connectivity between these regions. The purpose of this study was to characterize the effect of DLPFC stimulation on ipsilateral M1 excitability while participants were at rest and contracting the left- and right-hand first dorsal interosseous muscle. Twelve participants were tested in two separate sessions at varying inter-stimulus intervals (ISI: 4, 5, 6, 7, 8, 9, 10, 11, 12, 15, and 20 ms) at two different conditioning stimulus intensities (80% and 120% of resting motor threshold). No significant effect on ipsilateral M1 excitability was found when applying a conditioning stimulus over DLPFC at any specific inter-stimulus interval or intensity in either the left or right hemisphere. Our findings suggest neither causal inhibitory nor faciliatory influences of DLPFC on ipsilateral M1 activity while participants were at rest or when performing an isometric contraction in the target hand muscle.

Indexed as

connectivitydorsolateral prefrontal cortexmotor controlprimary motor cortextranscranial magnetic stimulation

Identifiers

PMID31357468
PMCPMC6721325

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.