Evidence map›Paper›PMID 31357453›Full record

ArticleMolecules (Basel, Switzerland)2019

Design, Synthesis and Biological Evaluation of 1-Phenyl-2-(phenylamino) Ethanone Derivatives as Novel MCR-1 Inhibitors.

Xiu-Juan Lan, Hai-Tao Yan, Feng Lin, Shi Hou, Chen-Chen Li, Guang-Shu Wang, Wei Sun, Jun-Hai Xiao, Song Li

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
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  11. Recent progress on elucidating the molecular mechanism of plasmid-mediated colistin resistance and drug design.International microbiology : the official journal of the Spanish Society for Microbiology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Xiu-Juan LanSchool of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.
Hai-Tao YanState Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
Feng LinSchool of Life Sciences, Jilin University, Changchun 130021, China.
Shi HouSchool of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.
Chen-Chen LiSchool of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.
Guang-Shu WangSchool of Pharmaceutical Sciences, Jilin University, Changchun 130021, China. wgs@jlu.edu.cn.ORCID 0000-0003-0938-7507
Wei SunSchool of Pharmaceutical Sciences, Jilin University, Changchun 130021, China. wsun@jlu.edu.cn.
Jun-Hai XiaoNational Engineering Research Center for Strategic Drugs, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China. xiaojunhai@139.com.
Song LiNational Engineering Research Center for Strategic Drugs, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polymyxins are considered to be the last-line antibiotics that are used to treat infections caused by multidrug-resistant (MDR) gram-negative bacteria; however, the plasmid-mediated transferable colistin resistance gene (

Indexed as

Drug DesignBacterial ProteinsChemistry Techniques, SyntheticComputer SimulationModels, MolecularPhosphotransferasesStructure-Activity RelationshipBacterial ProteinsPhosphotransferases1-phenyl-2-(phenylamino) ethanone derivativesColistin resistanceMCR-1 inhibitorsvirtual screening

Identifiers

PMID31357453
PMCPMC6696459
OpenAlexW2965796252

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.