ReviewInternational journal of molecular sciences2019
Cell-Free Nucleic Acids and their Emerging Role in the Pathogenesis and Clinical Management of Inflammatory Bowel Disease.
Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Review
- Common microbial signatures in blood and their amplification in clinical disorders.Gut microbes reports · 2025Review
- Extrachromosomal Circular DNA: An Emerging Potential Biomarker for Inflammatory Bowel Diseases?Genes · 2024Review
- Can Serum Histone H4 Level Be a Biomarker in Ulcerative Colitis?The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2024Article
- Investigation of the Presence of DNA in Human Blood Plasma Small Extracellular Vesicles.International journal of molecular sciences · 2023Article
- Microsatellite instability assessment is instrumental for Predictive, Preventive and Personalised Medicine: status quo and outlook.The EPMA journal · 2023Review
- Impaired Abcb1a function and red meat in a translational colitis mouse model induces inflammation and alters microbiota composition.Frontiers in medicine · 2023Article
- 5-Hydroxymethylcytosines in circulating cell-free DNA reveal a diagnostic biomarker for glioma.Heliyon · 2022Article
- Machine learning-based detection of immune-mediated diseases from genome-wide cell-free DNA sequencing datasets.NPJ genomic medicine · 2022Article
- Hemp-Derived Nanovesicles Protect Leaky Gut and Liver Injury in Dextran Sodium Sulfate-Induced Colitis.International journal of molecular sciences · 2022Article
- Article
- Comparative metagenomics analysis reveals how the diet shapes the gut microbiota in several small mammals.Ecology and evolution · 2022Article
- Serum exosomal pregnancy zone protein as a promising biomarker in inflammatory bowel disease.Cellular & molecular biology letters · 2021Article
- Circulating Free DNA and Its Emerging Role in Autoimmune Diseases.Journal of personalized medicine · 2021Review
- Extracellular DNA Correlates with Intestinal Inflammation in Chemically Induced Colitis in Mice.Cells · 2021Article
- Cationic Nanomaterials for Autoimmune Diseases Therapy.Frontiers in pharmacology · 2021Review
- The Role of Neutrophil Extracellular Traps in Cancer.Frontiers in oncology · 2021Review
- Role and mechanisms of exosomal miRNAs in IBD pathophysiology.American journal of physiology. Gastrointestinal and liver physiology · 2020Review
- Technical and Methodological Aspects of Cell-Free Nucleic Acids Analyzes.International journal of molecular sciences · 2020Review
- Exosome-mediated effects and applications in inflammatory bowel disease.Biological reviews of the Cambridge Philosophical Society · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell-free nucleic acids (cfNAs) are defined as any nucleic acids that are present outside the cell. They represent valuable biomarkers in various diagnostic protocols such as prenatal diagnostics, the detection of cancer, and cardiovascular or autoimmune diseases. However, in the current literature, little is known about their implication in inflammatory bowel disease (IBD). IBD is a group of multifactorial, autoimmune, and debilitating diseases with increasing incidence worldwide. Despite extensive research, their etiology and exact pathogenesis is still unclear. Since cfNAs were observed in other autoimmune diseases and appear to be relevant in inflammatory processes, their role in the pathogenesis of IBD has also been suggested. This review provides a summary of knowledge from the available literature about cfDNA and cfRNA and the structures involving them such as exosomes and neutrophil extracellular traps and their association with IBD. Current studies showed the promise of cfNAs in the management of IBD not only as biomarkers distinguishing patients from healthy people and differentiating active from inactive disease state, but also as a potential therapeutic target. However, the detailed biological characteristics of cfNAs need to be fully elucidated in future experimental and clinical studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.