ArticleiScience2019
Bacterial Cheaters Evade Punishment by Cyanide.
Article in iScience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Biophysical Constraints Dictate the Stability of Social Traits inbioRxiv : the preprint server for biology · 2026Article
- Exploring cooperation among social pathogens: a computational perspective.FEMS microbiology reviews · 2026Review
- Malonate is relevant to the lung environment and induces genome-wide stress responses in Pseudomonas aeruginosa.Research square · 2024Article
- Article
- Trojan horselike T6SS effector TepC mediates both interference competition and exploitative competition.The ISME journal · 2024Article
- Putting theory to the test: An integrated computational/experimental chemostat model of the tragedy of the commons.PloS one · 2024Article
- Cyanide emerges as an endogenous mammalian gasotransmitter.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- A Bacterial Tower of Babel: Quorum-Sensing Signaling Diversity and Its Evolution.Annual review of microbiology · 2020Review
- Seeding Public Goods Is Essential for Maintaining Cooperation inFrontiers in microbiology · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In all domains of life, mechanisms exist that protect cooperating groups from exploitation by cheaters. Recent observations with the bacterium Pseudomonas aeruginosa have suggested a paradigmatic cheater control mechanism in which cooperator cells punish or "police" cheater cells by cyanide poisoning. These cheater cells are deficient in a pleiotropic quorum-sensing regulator that controls the production of cooperative secretions including cyanide, and presumably also cyanide resistance. In this study, we directly tested and refuted the cyanide policing model. Contrary to the hypothesis, cheater fitness was unaffected by the presence of cyanide. Cheater mutants grew equally well in co-cultures with either cyanide-proficient or cyanide-deficient cooperators, and they were as resistant to exogenous cyanide as wild-type cells. We show that these behaviors are the result of quorum-sensing-independent and cyanide-responsive resistance gene regulation. Our results highlight the role of genetic architecture in the evolution of cooperative behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.