Evidence map›Paper›PMID 31357155›Full record

ArticleEnvironmental research2019

Unconventional natural gas development and adverse birth outcomes in Pennsylvania: The potential mediating role of antenatal anxiety and depression.

Joan A Casey, Dana E Goin, Kara E Rudolph, Brian S Schwartz, Dione Mercer, Holly Elser, Ellen A Eisen, Rachel Morello-Frosch

Abstract read
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In one paragraph

Article in Environmental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  19. Shale Gas Development and Community Distress: Evidence from England.International journal of environmental research and public health · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Joan A CaseyDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, USA; Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA. Electronic address: jac2250@columbia.edu.
Dana E GoinDivision of Epidemiology, School of Public Health, University of California, Berkeley, USA.
Kara E RudolphDepartment of Emergency Medicine, School of Medicine, University of California, Davis, Sacramento, CA, USA.
Brian S SchwartzDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Epidemiology and Health Services Research, Geisinger, Danville, PA, USA; Johns Hopkins School of Medicine, Department of Medicine, Baltimore, MD, USA.
Dione MercerDepartment of Epidemiology and Health Services Research, Geisinger, Danville, PA, USA.
Holly ElserDivision of Epidemiology, School of Public Health, University of California, Berkeley, USA.
Ellen A EisenDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, USA.
Rachel Morello-FroschDivision of Community Health Sciences, School of Public Health, University of California, Berkeley, USA; College of Natural Resources Department of Environmental Science, Policy, & Management, University of California, Berkeley, USA.

Funding

Training CoreP42ES004705 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI SMITH, MARTYN T · 1987 to 2025
$74.6M
The Illinois Kids Development Study ECHO Pregnancy and Pediatric CohortUH3OD023272 · OD · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Andrea Aguiar, Susan L Schantz · 2018 to 2026
$18.6M
The Illinois Kids Development Study ECHO Pregnancy and Pediatric CohortUG3OD023272 · OD · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI SCHANTZ, SUSAN L · 2016 to 2024
$7.2M
Mechanisms linking neighborhood poverty to problematic adolescent drug useR00DA042127 · NIDA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI RUDOLPH, KARA ELIZABETH · 2018 to 2021
$889k
The Impact of Unconventional Natural Gas Development on Maternal, Perinatal, and Childhood Health: an Electronic Health Record ApproachR00ES027023 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CASEY, JOAN A · 2019 to 2021
$747k
The impact of unconventional natural gas development on maternal, perinatal, and childhood health: An electronic health record approachK99ES027023 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CASEY, JOAN A · 2017 to 2018
$203k
NIDA NIH HHS R00 DA042127NIEHS NIH HHS K99 ES027023NIEHS NIH HHS P42 ES004705NIEHS NIH HHS R00 ES027023NIH HHS UG3 OD023272NIH HHS UH3 OD023272
6 · The paper itself

Abstract

backgroundStudies have reported associations between unconventional natural gas development (UNGD) and adverse birth outcomes. None have evaluated potential mediating mechanisms.

objectivesTo evaluate associations between (1) UNGD and antenatal anxiety and depression and (2) antenatal anxiety and depression and preterm birth (<37 weeks gestation) and reduced term birth weight, (3) stochastic direct and indirect effects of UNGD on preterm birth and term birth weight operating through antenatal anxiety and depression, and (4) effect modification by family-level socioeconomic status.

methodsThis retrospective cohort study included mothers without prevalent anxiety or depression at time of conception, who delivered at Geisinger in Pennsylvania between January 2009-January 2013. We assembled phase-specific UNGD activity data from public sources. Mothers were categorized as exposed (quartile 4) or unexposed (quartiles 1-3) based on average daily inverse distance-squared UNGD activity metric between conception and the week prior to anxiety or depression (cases) or the pregnancy-average daily metric (non-cases). We estimated associations with a doubly robust estimator (targeted minimum loss-based estimation) and adjusted for potential individual- and community-level confounding variables.

resultsAnalyses included 8,371 births to 7,715 mothers, 12.2% of whom had antenatal anxiety or depression. We found 4.3 additional cases of antenatal anxiety or depression per 100 women (95% CI: 1.5, 7.0) under the scenario where all mothers lived in the highest quartile of UNGD activity versus quartiles 1-3. The risk difference appeared larger among mothers receiving Medical Assistance (indicator of low family income) compared to those who did not, 5.6 (95% CI: 0.5, 10.6) versus 2.9 (95% CI: -0.7, 6.5) additional cases of antenatal anxiety or depression per 100 women. We found no relationship between antenatal anxiety or depression and adverse birth outcomes and no mediation effect either overall or when stratifying by Medical Assistance.

conclusionWe observed a relationship between UNGD activity and antenatal anxiety and depression, which did not mediate the overall association between UNGD activity and adverse birth outcomes.

Indexed as

Natural GasAnxietyDepressionFemaleHumansInfant, NewbornMaleMaternal ExposurePennsylvaniaPregnancyPregnancy ComplicationsPregnancy OutcomePremature BirthRetrospective StudiesNatural GasAnxietyDepressive disorderHydraulic frackingMaternal healthSocial class

Identifiers

PMID31357155
PMCPMC6726131

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.