Evidence map›Paper›PMID 31356958›Full record

ArticleAnaerobe2020

Molecular epidemiology of toxigenic Clostridioides difficile isolates from hospitalized patients and the hospital environment in Dhaka, Bangladesh.

Amelia K Sofjan, Mohammad Aminul Islam, Kakali Halder, Nayel D Kabir, Ahmed Abu Saleh, Julie Miranda, Chris Lancaster, Khurshida Begum, M Jahangir Alam, Kevin W Garey

Abstract read
In one paragraph

Article in Anaerobe, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Best Practices in the Management ofTropical medicine and infectious disease · 2024
    Review
  3. Make It LessGenes · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Amelia K SofjanUniversity of Houston College of Pharmacy, 4849 Calhound Road, Houston, TX, USA. Electronic address: aksofjan@uh.edu.
Mohammad Aminul IslamInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), 68, Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka, 1212, Bangladesh; Paul G. Allen School for Global Animal Health, Washington State University, Pullman, WA, 99164, USA.
Kakali HalderBangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka, 1000, Bangladesh.
Nayel D KabirInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), 68, Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka, 1212, Bangladesh.
Ahmed Abu SalehBangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka, 1000, Bangladesh.
Julie MirandaUniversity of Houston College of Pharmacy, 4849 Calhound Road, Houston, TX, USA.
Chris LancasterUniversity of Houston College of Pharmacy, 4849 Calhound Road, Houston, TX, USA.
Khurshida BegumUniversity of Houston College of Pharmacy, 4849 Calhound Road, Houston, TX, USA.
M Jahangir AlamUniversity of Houston College of Pharmacy, 4849 Calhound Road, Houston, TX, USA.
Kevin W GareyUniversity of Houston College of Pharmacy, 4849 Calhound Road, Houston, TX, USA.

Funding

Decoding Antibiotic-induced Susceptibility to Clostridium difficile InfectionU01AI124290 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI BRITTON, ROBERT A, GAREY, KEVIN W · 2016 to 2020
$7.9M
NIAID NIH HHS U01 AI124290
6 · The paper itself

Abstract

Epidemiology of Clostridioides difficile (syn. Clostridium difficile) infection (CDI) in Bangladesh is poorly understood. This study assessed the epidemiology of CDI in hospitalized patients and hospital environmental contamination of toxigenic C. difficile at two large urban Bangladesh hospitals. This 12-month prospective observational cohort study collected stool samples from adults with diarrhea and recent antimicrobial exposure during 2017. Environmental samples were collected by swabbing surfaces of hospital common areas. Samples underwent toxigenic culture. C. difficile isolates were tested for toxins A and B and PCR-ribotyped. Of 208 stool samples, 18 (8.7%) were positive for toxigenic C. difficile. Of 400 environmental samples, 45 (11%) were positive for toxigenic C. difficile. Ribotypes present in ≥10% of stool isolates were 017 (38%), 053-163 (13%), and a novel ribotype (FP435 [13%]). Common ribotypes in environmental isolates were 017 (22%), 053-163 (11%), 106 (24%). This is the first report describing current epidemiology of CDI in at risk hospitalized adult patients in Bangladesh.

Indexed as

Cross InfectionHospitalsAdultBacterial ToxinsBangladeshClostridioides difficileClostridium InfectionsFemaleHumansMaleMiddle AgedMolecular EpidemiologyPublic Health SurveillanceRibotypingBacterial ToxinsAsiaClostridium difficileDeveloping countriesProspective studies

Identifiers

PMID31356958
PMCPMC7315644

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.