ArticlePLoS genetics2019
miR-210 controls the evening phase of circadian locomotor rhythms through repression of Fasciclin 2.
Article in PLoS genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- tca-miR-3835-5p-ACPR-ACC neuroendocrine axis controls locomotor behavior via lipid metabolism in Tribolium castaneum.Pest management science · 2026Article
- Temporal miRNA Biomarkers for Pupal Age Estimation inInsects · 2025Article
- miR-2940-1 is involved in the circadian regulation of oviposition in Aedes albopictus.Insect science · 2025Article
- Light-regulated microRNAs shape dynamic gene expression in the zebrafish circadian clock.PLoS genetics · 2025Article
- Identification of miRNAs Involved in Olfactory Regulation in Antennae of Beet Webworm,Life (Basel, Switzerland) · 2024Article
- miR-210 is essential to retinal homeostasis in fruit flies and mice.Biology direct · 2024Article
- NF-κB factors cooperate with Su(Hw)/E4F1 to balance Drosophila/human immune responses via modulating dynamic expression of miR-210.Nucleic acids research · 2024Article
- Review
- miR-277 regulates the phase of circadian activity-rest rhythm inFrontiers in physiology · 2023Article
- Profiling ATM regulated genes in Drosophila at physiological condition and after ionizing radiation.Hereditas · 2022Article
- The Role of microRNAs in theFrontiers in cell and developmental biology · 2022Review
- Neurofibromin 1 in mushroom body neurons mediates circadian wake drive through activating cAMP-PKA signaling.Nature communications · 2021Article
- Post-transcriptional modulators and mediators of the circadian clock.Chronobiology international · 2021Review
- Translating around the clock: Multi-level regulation of post-transcriptional processes by the circadian clock.Cellular signalling · 2021Review
- The conserved microRNA miR-210 regulates lipid metabolism and photoreceptor maintenance in the Drosophila retina.Cell death and differentiation · 2021Article
- Profiling of MicroRNAs in Midguts ofFrontiers in genetics · 2021Article
- MicroRNA: A Key Player for the Interplay of Circadian Rhythm Abnormalities, Sleep Disorders and Neurodegenerative Diseases.Clocks & sleep · 2020Review
- Better Sleep at Night: How Light Influences Sleep inFrontiers in physiology · 2020Review
- Article
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Authors and funding
5 authors.
Funding
Abstract
Circadian clocks control the timing of animal behavioral and physiological rhythms. Fruit flies anticipate daily environmental changes and exhibit two peaks of locomotor activity around dawn and dusk. microRNAs are small non-coding RNAs that play important roles in post-transcriptional regulation. Here we identify Drosophila miR-210 as a critical regulator of circadian rhythms. Under light-dark conditions, flies lacking miR-210 (miR-210KO) exhibit a dramatic 2 hrs phase advance of evening anticipatory behavior. However, circadian rhythms and molecular pacemaker function are intact in miR-210KO flies under constant darkness. Furthermore, we identify that miR-210 determines the evening phase of activity through repression of the cell adhesion molecule Fasciclin 2 (Fas2). Ablation of the miR-210 binding site within the 3' UTR of Fas2 (Fas2ΔmiR-210) by CRISPR-Cas9 advances the evening phase as in miR-210KO. Indeed, miR-210 genetically interacts with Fas2. Moreover, Fas2 abundance is significantly increased in the optic lobe of miR-210KO. In addition, overexpression of Fas2 in the miR-210 expressing cells recapitulates the phase advance behavior phenotype of miR-210KO. Together, these results reveal a novel mechanism by which miR-210 regulates circadian locomotor behavior.
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