Evidence map›Paper›PMID 31356166›Full record

ArticleImmunoHorizons2019

Deficiency of Mucosal-Associated Invariant T Cells in TCRJα18 Germline Knockout Mice.

Jinhai Xie, Yun Pan, Huishan Tao, Peng Wang, Yongping Chen, Jimin Gao, Xiao-Ping Zhong

Open access · goldAbstract read
In one paragraph

Article in ImmunoHorizons, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Tissue-Resident Memory CD4Journal of immunology (Baltimore, Md. : 1950) · 2022
    Article
  6. Review
  7. Article
  8. Mouse models illuminate MAIT cell biology.Molecular immunology · 2021
    Review
  9. MicroRNA-155 Regulates MAIT1 and MAIT17 Cell Differentiation.Frontiers in cell and developmental biology · 2021
    Article
  10. Article
  11. Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Jinhai XieDivision of Allergy and Immunology, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710.
Yun PanSchool of Laboratory Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Huishan TaoDivision of Allergy and Immunology, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710.
Peng WangDivision of Allergy and Immunology, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710.
Yongping ChenDepartment of Infectious Diseases, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Jimin GaoSchool of Laboratory Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; xiaoping.zhong@duke.edu jimingao64@163.com.ORCID 0000-0002-3911-043X
Xiao-Ping ZhongDivision of Allergy and Immunology, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710; xiaoping.zhong@duke.edu jimingao64@163.com.ORCID 0000-0002-4619-8783
Wenzhou Medical University · CNDuke Medical Center · US

Funding

Regulation of peripheral T cell toleranceR01AI079088 · NIAID · DUKE UNIVERSITY · PI ZHONG, XIAOPING · 2008 to 2019
$3.5M
TSC1-mTOR signaling and T cell toleranceR01AI101206 · NIAID · DUKE UNIVERSITY · PI ZHONG, XIAOPING · 2012 to 2016
$1.9M
NIAID NIH HHS R01 AI079088NIAID NIH HHS R01 AI101206
6 · The paper itself

Abstract

Mucosal-associated invariant T (MAIT) cells and invariant NK T (iNKT) cells account for the major lymphocyte populations that express invariant TCRα-chains. MAIT cells mostly express the TCRVα19-Jα33 TCR in mice and the TCRVα7.2-Jα33 TCR in humans, whereas iNKT cells express the TCRVα14-Jα18 TCR in mice and the TCRVα24-Jα18 TCR in humans. Both MAIT and iNKT cells have the capacity to quickly produce a variety of cytokines in response to agonist stimuli and to regulate both innate and adaptive immunity. The germline TCRJα18 knockout (

Indexed as

Genes, T-Cell Receptor alphaAdoptive TransferAnimalsCells, CulturedCytokinesGerm-Line MutationHumansLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutMucosal-Associated Invariant T CellsMucous MembraneNatural Killer T-CellsReceptors, Antigen, T-CellReceptors, Antigen, T-Cell, alpha-betaCytokinesReceptors, Antigen, T-CellReceptors, Antigen, T-Cell, alpha-betaTraj18 protein, mouseValpha24 protein, human

Identifiers

PMID31356166
PMCPMC6829908
OpenAlexW2951627891

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.