ArticleCirculation2019
Depletion of Endothelial Prolyl Hydroxylase Domain Protein 2 and 3 Promotes Cardiomyocyte Proliferation and Prevents Ventricular Failure Induced by Myocardial Infarction.
Open access · bronzeAbstract readLetter
In one paragraph
Article in Circulation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Cell-free strategies for cardiomyocyte proliferation and heart repair.Pharmacological reports : PR · 2026Review
- Molecular gatekeepers of endogenous adult mammalian cardiomyocyte proliferation.Nature reviews. Cardiology · 2025Review
- Inhibition of BMPER Mitigates Pulmonary Hypertension by Modulating LRP1-YAP Interaction in Smooth Muscle Cells.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Article
- Cardiac repair using regenerating neonatal heart tissue-derived extracellular vesicles.Nature communications · 2025Article
- Hypoxia-induced stabilization of HIF2A promotes cardiomyocyte proliferation by attenuating DNA damage.The journal of cardiovascular aging · 2024Article
- Extracellular vesicle-derived CircWhsc1 promotes cardiomyocyte proliferation and heart repair by activating TRIM59/STAT3/Cyclin B2 pathway.Journal of advanced research · 2023Article
- YAP/TAZ: Molecular pathway and disease therapy.MedComm · 2023Review
- Phagocytosing differentiated cell-fragments is a novel mechanism for controlling somatic stem cell differentiation within a short time frame.Cellular and molecular life sciences : CMLS · 2022Article
- Coupled myovascular expansion directs cardiac growth and regeneration.Development (Cambridge, England) · 2022Article
- The regenerative capacity of neonatal tissues.Development (Cambridge, England) · 2022Review
- Extracellular vesicle-packaged mitochondrial disturbing miRNA exacerbates cardiac injury during acute myocardial infarction.Clinical and translational medicine · 2022Article
- Article
- Loss of Endothelial Hypoxia Inducible Factor-Prolyl Hydroxylase 2 Induces Cardiac Hypertrophy and Fibrosis.Journal of the American Heart Association · 2021Article
- ALKBH5 regulates cardiomyocyte proliferation and heart regeneration by demethylating the mRNA of YTHDF1.Theranostics · 2021Article
- Endothelial prolyl hydroxylase 2 is necessary for angiotensin II-mediated renal fibrosis and injury.American journal of physiology. Renal physiology · 2020Article
- Pressure Overload Greatly Promotes Neonatal Right Ventricular Cardiomyocyte Proliferation: A New Model for the Study of Heart Regeneration.Journal of the American Heart Association · 2020Article
- Toward the Goal of Human Heart Regeneration.Cell stem cell · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Qiying FanCardiovascular Research Institute, Department of Medicine (Q.F., H.M., A.A., X.H.T.W., X.P., L.X.), Baylor College of Medicine, Houston, TX.
Hua MaoCardiovascular Research Institute, Department of Medicine (Q.F., H.M., A.A., X.H.T.W., X.P., L.X.), Baylor College of Medicine, Houston, TX.
Aude AngeliniCardiovascular Research Institute, Department of Medicine (Q.F., H.M., A.A., X.H.T.W., X.P., L.X.), Baylor College of Medicine, Houston, TX.
Cristian CoarfaDepartments of Molecular and Cellular Biology (C.C., M.J.R.), Baylor College of Medicine, Houston, TX.
Matthew J RobertsonDepartments of Molecular and Cellular Biology (C.C., M.J.R.), Baylor College of Medicine, Houston, TX.
William R LagorDepartment of Molecular Physiology and Biophysics (W.R.L., X.H.T.W., J.F.M.), Baylor College of Medicine, Houston, TX.
Xander H T WehrensCardiovascular Research Institute, Department of Medicine (Q.F., H.M., A.A., X.H.T.W., X.P., L.X.), Baylor College of Medicine, Houston, TX.
James F MartinDepartment of Molecular Physiology and Biophysics (W.R.L., X.H.T.W., J.F.M.), Baylor College of Medicine, Houston, TX.
Xinchun PiCardiovascular Research Institute, Department of Medicine (Q.F., H.M., A.A., X.H.T.W., X.P., L.X.), Baylor College of Medicine, Houston, TX.
Liang XieCardiovascular Research Institute, Department of Medicine (Q.F., H.M., A.A., X.H.T.W., X.P., L.X.), Baylor College of Medicine, Houston, TX.
Baylor College of Medicine · US
Funding
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DAVID R ROWLEY · 2007 to 2026
$73.9MTranslational Research Support CoreP30ES030285 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI Cheryl L. Walker · 2019 to 2026
$14.7MSignaling in endothelial growth & angiogenesisR01HL061656 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PI, XINCHUN · 1999 to 2017
$5.8MNovel roles of Fe (2+), 2-oxoglutarate-dependent dioxygenases in cardiac functionR01HL122736 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI XIE, LIANG · 2016 to 2020
$2.0MLRP1 and endothelial functionR01HL112890 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PI, XINCHUN · 2013 to 2017
$1.9MNCI NIH HHS P30 CA125123NHLBI NIH HHS R01 HL061656NHLBI NIH HHS R01 HL112890NHLBI NIH HHS R01 HL122736NIEHS NIH HHS P30 ES030285
Abstract
PubMed holds no abstract for this paper.
Indexed as
AnimalsCell ProliferationEndothelium, VascularHeart FailureHypoxia-Inducible Factor-Proline DioxygenasesMiceMice, KnockoutMice, TransgenicMyocardial InfarctionMyocytes, CardiacProcollagen-Proline DioxygenaseVentricular Dysfunction, LeftEgln1 protein, mouseHypoxia-Inducible Factor-Proline DioxygenasesPHD3 protein, mouseProcollagen-Proline Dioxygenasecell proliferationendothelial cellsheart failurehypoxiamyocardial infarctionmyocytes, cardiacregeneration
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What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.