Evidence map›Paper›PMID 31356052›Full record

ArticleAnalytical chemistry2019

8-plex LC-MS/MS Analysis of Permethylated

Xue Dong, Wenjing Peng, Chuan-Yih Yu, Shiyue Zhou, Kaitlyn B Donohoo, Haixu Tang, Yehia Mechref

Abstract read
In one paragraph

Article in Analytical chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Separation of PermethylatedMetabolites · 2020
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xue DongDepartment of Chemistry & Biochemistry , Texas Tech University , Lubbock , Texas 79409 , United States.
Wenjing PengDepartment of Chemistry & Biochemistry , Texas Tech University , Lubbock , Texas 79409 , United States.
Chuan-Yih YuSchool of Informatics & Computing , Indiana University , Bloomington , Indiana 47408 , United States.
Shiyue ZhouDepartment of Chemistry & Biochemistry , Texas Tech University , Lubbock , Texas 79409 , United States.
Kaitlyn B DonohooDepartment of Chemistry & Biochemistry , Texas Tech University , Lubbock , Texas 79409 , United States.
Haixu TangSchool of Informatics & Computing , Indiana University , Bloomington , Indiana 47408 , United States.
Yehia MechrefDepartment of Chemistry & Biochemistry , Texas Tech University , Lubbock , Texas 79409 , United States.ORCID 0000-0002-6661-6073

Funding

Sensitive and Quantitative MS-bases Glycomic Mapping PlatformR01GM112490 · NIGMS · TEXAS TECH UNIVERSITY · PI MECHREF, YEHIA · 2014 to 2024
$3.2M
Quantitative Characterization of Glycopeptide IsomersR01GM130091 · NIGMS · TEXAS TECH UNIVERSITY · PI Yehia Mechref · 2019 to 2026
$2.5M
NIGMS NIH HHS R01 GM112490NIGMS NIH HHS R01 GM130091
6 · The paper itself

Abstract

Glycosylation is an important post-translational modification of proteins. Many diseases, such as cancer, have proved to be related to aberrant glycosylation. High throughput quantitative methods have gained attention recently in the study of glycomics. With the development of high-resolution mass spectrometry, the sensitivity of detection in glycomics has largely improved; however, most of the commonly used MS-based techniques are focused on relative quantitative analysis, which can hardly provide direct comparative glycomic quantitation results. In this study, we developed a novel multiplex glycomic analysis method on an LC-ESI-MS platform. Reduced glycans were stable isotopic labeled during the permethylation procedure, with the use of iodomethane reagents CH

Indexed as

Brain NeoplasmsBreast NeoplasmsCarbon IsotopesCell Line, TumorChromatography, LiquidFemaleGlycomicsGlycoproteinsHumansHydrocarbons, IodinatedMethylationPolysaccharidesReproducibility of ResultsSpectrometry, Mass, Electrospray IonizationTandem Mass SpectrometryCarbon-13Carbon IsotopesGlycoproteinsHydrocarbons, Iodinatedmethyl iodidePolysaccharides

Identifiers

PMID31356052
PMCPMC7412976

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.