Evidence map›Paper›PMID 31355994›Full record

ArticleHuman brain mapping2019

Refined measure of functional connectomes for improved identifiability and prediction.

Biao Cai, Gemeng Zhang, Wenxing Hu, Aiying Zhang, Pascal Zille, Yipu Zhang, Julia M Stephen, Tony W Wilson, Vince D Calhoun, Yu-Ping Wang

Abstract read
In one paragraph

Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Biao CaiBiomedical Engineering Department, Tulane University, New Orleans, Louisiana.ORCID 0000-0002-2706-4982
Gemeng ZhangBiomedical Engineering Department, Tulane University, New Orleans, Louisiana.
Wenxing HuBiomedical Engineering Department, Tulane University, New Orleans, Louisiana.
Aiying ZhangBiomedical Engineering Department, Tulane University, New Orleans, Louisiana.ORCID 0000-0001-9623-3922
Pascal ZilleBiomedical Engineering Department, Tulane University, New Orleans, Louisiana.
Yipu ZhangSchool of Electronics and Control Engineering, Chang'an University, Xi'an, Shaanxi, China.
Julia M StephenTri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, Georgia.
Tony W WilsonDepartment of Neurological Sciences, University of Nebraska Medical Center (UNMC), Omaha, Nebraska.ORCID 0000-0002-5053-8306
Vince D CalhounTri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, Georgia.
Yu-Ping WangBiomedical Engineering Department, Tulane University, New Orleans, Louisiana.

Funding

THE PROGRESSIVE ELEVATION OF SPONTANEOUS CORTICAL ACTIVITY IN HAND (PESCAH) PROJECTR01MH116782 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WILSON, TONY W · 2018 to 2022
$3.4M
Neurophysiological markers of HAND and the impact of aging: Evidence from MEGR01MH103220 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WILSON, TONY W · 2014 to 2018
$2.5M
Integration of brain imaging with genomic and epigenomic dataR01MH104680 · NIMH · TULANE UNIVERSITY OF LOUISIANA · PI CALHOUN, VINCE D, DENG, HONG-WEN · 2014 to 2017
$2.1M
Integration of fMRI imaging, genomics, network and biological knowledgeR01MH107354 · NIMH · TULANE UNIVERSITY OF LOUISIANA · PI WANG, YU-PING · 2015 to 2018
$1.9M
Integration of multiscale genomic data for comprehensive analysis of complex diseR01GM109068 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI WANG, YU-PING · 2014 to 2018
$1.6M
National Science Foundation 1539067NIGMS NIH HHS R01 GM109068NIH HHS P20 GM109068NIH HHS R01 MH103220NIH HHS R01 MH104680NIH HHS R01 MH107354NIMH NIH HHS R01 MH103220NIMH NIH HHS R01 MH104680NIMH NIH HHS R01 MH107354NIMH NIH HHS R01 MH116782
6 · The paper itself

Abstract

Brain functional connectome analysis is commonly based on population-wise inference. However, in this way precious information provided at the individual subject level may be overlooked. Recently, several studies have shown that individual differences contribute strongly to the functional connectivity patterns. In particular, functional connectomes have been proven to offer a fingerprint measure, which can reliably identify a given individual from a pool of participants. In this work, we propose to refine the standard measure of individual functional connectomes using dictionary learning. More specifically, we rely on the assumption that each functional connectivity is dominated by stable group and individual factors. By subtracting population-wise contributions from connectivity patterns facilitated by dictionary representation, intersubject variability should be increased within the group. We validate our approach using several types of analyses. For example, we observe that refined connectivity profiles significantly increase subject-specific identifiability across functional magnetic resonance imaging (fMRI) session combinations. Besides, refined connectomes can also improve the prediction power for cognitive behaviors. In accordance with results from the literature, we find that individual distinctiveness is closely linked with differences in neurocognitive activity within the brain. In summary, our results indicate that individual connectivity analysis benefits from the group-wise inferences and refined connectomes are indeed desirable for brain mapping.

Indexed as

ConnectomeAdolescentAgingAlgorithmsBrainBrain MappingChildCognitionFemaleHumansIndividualityMachine LearningMagnetic Resonance ImagingMaleMemory, Short-TermNerve Netcognitive behavior predictionfunctional connectivityindividual identificationrefined connectomessparse dictionary learning model

Identifiers

PMID31355994
PMCPMC6865523

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.