Evidence map›Paper›PMID 31355979›Full record

ArticleNMR in biomedicine2019

Noninvasive quantitative magnetization transfer MRI reveals tubulointerstitial fibrosis in murine kidney.

Feng Wang, Suwan Wang, Yahua Zhang, Ke Li, Raymond C Harris, John C Gore, Ming-Zhi Zhang

Abstract read
In one paragraph

Article in NMR in biomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Feng WangVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, TN, 37232, USA.ORCID 0000-0002-8965-7708
Suwan WangDivision of Nephrology and Hypertension, Vanderbilt University Medical Center, TN, USA.
Yahua ZhangDivision of Nephrology and Hypertension, Vanderbilt University Medical Center, TN, USA.
Ke LiVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, TN, 37232, USA.
Raymond C HarrisDivision of Nephrology and Hypertension, Vanderbilt University Medical Center, TN, USA.
John C GoreVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, TN, 37232, USA.
Ming-Zhi ZhangDivision of Nephrology and Hypertension, Vanderbilt University Medical Center, TN, USA.

Funding

The Role of the EGF Receptor in Acute and Chronic Renal InjuryR01DK051265 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RAYMOND C. HARRIS, Mingzhi Zhang · 1997 to 2026
$10.1M
The role of the innate immune cell cyclooxygenase/prostaglandin system in blood pressureregulationR01DK062794 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RAYMOND C. HARRIS, Mingzhi Zhang · 2003 to 2026
$9.4M
The Role of renal macrophages in recovery from renal injuryR01DK095785 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RAYMOND C. HARRIS, Mingzhi Zhang · 2013 to 2026
$6.7M
Novel Integrated Analyses of Human Diabetic NephropathyR24DK103067 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CAPRIOLI, RICHARD M, DENNY, JOSHUA C. · 2014 to 2018
$6.5M
Vanderbilt O'Brien Kidney Center - Core D - Clinical and Translational CoreP30DK114809 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DE CAESTECKER, MARK P. · 2017 to 2021
$5.9M
Proton Relaxation and Exchange Contrast in MRIR01EB024525 · NIBIB · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZU, ZHONGLIANG · 2018 to 2021
$2.0M
Upgrade of a 7T Small Animal MRI/MRS SystemS10OD019993 · OD · VANDERBILT UNIVERSITY · PI GORE, JOHN C · 2015 to 2015
$600k
BLRD VA I01 BX000320NIBIB NIH HHS R01 EB024525NIDDK NIH HHS P30 DK114809NIDDK NIH HHS R01 DK051265NIDDK NIH HHS R01 DK062794NIDDK NIH HHS R01 DK095785NIDDK NIH HHS R24 DK103067NIH HHS S10 OD019993
6 · The paper itself

Abstract

Excessive tissue scarring, or fibrosis, is a critical contributor to end stage renal disease, but current clinical tests are not sufficient for assessing renal fibrosis. Quantitative magnetization transfer (qMT) MRI provides indirect information about the macromolecular composition of tissues. We evaluated measurements of the pool size ratio (PSR, the ratio of immobilized macromolecular to free water protons) obtained by qMT as a biomarker of tubulointerstitial fibrosis in a well-established murine model with progressive renal disease. MR images were acquired from 16-week-old fibrotic hHB-EGF

Indexed as

Magnetic Resonance ImagingAnimalsFibrosisHeparin-binding EGF-like Growth FactorHumansKidney MedullaKidney TubulesMaleMice, Inbred C57BLROC CurveHeparin-binding EGF-like Growth Factormagnetization transfer ratiopool size ratioquantitative magnetization transferrelaxationrenal fibrosis

Identifiers

PMID31355979
PMCPMC6817372

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.