ArticleReproduction in domestic animals = Zuchthygiene2019
Polymorphisms of the melatonin receptor 1A gene that affects the reproductive seasonality and litter size in Small Tail Han sheep.
Article in Reproduction in domestic animals = Zuchthygiene, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Population-Level Lambing Interval Patterns and Evaluation of Three Previously Reported Candidate SNPs in Hu and Tan Sheep.Animals : an open access journal from MDPI · 2026Article
- A Functional SNP in the Promoter Region of Ovine IDO2 Associated With Melatonin Levels via Affecting Transcription Activity by CLOCK.Animal genetics · 2026Article
- A novel p.127Val>Ile single nucleotide polymorphism in the MTNR1A gene and its relation to litter size in Thin-tailed Indonesian ewes.Animal bioscience · 2025Article
- Polymorphisms of theArchives animal breeding · 2024Article
- Polymorphism of theAnimals : an open access journal from MDPI · 2023Article
- Association between single-nucleotide polymorphism inAnimal biotechnology · 2023Article
- Photoperiod Induces DNA Methylation Changes in the Melatonin Receptor 1A Gene in Ewes.Animals : an open access journal from MDPI · 2023Article
- Article
- Association of melatonin receptor 1 A with litter size in sheep: A review.F1000Research · 2023Review
- Reproductive Resumption in Winter and Spring Related toAnimals : an open access journal from MDPI · 2022Article
- Transcriptomic Changes of Photoperiodic Response in the Hypothalamus Were Identified in Ovariectomized and Estradiol-Treated Sheep.Frontiers in molecular biosciences · 2022Article
- Genome-Wide Identification of mRNAs, lncRNAs, and Proteins, and Their Relationship With Sheep Fecundity.Frontiers in genetics · 2021Article
- Single-nucleotide polymorphisms inArchives animal breeding · 2021Article
- The effect of SNP rs400827589 in exon 2 of the MTNR1B gene on reproductive seasonality and litter size in sheep.Veterinary medicine and science · 2020Article
- TGIF1 and SF1 polymorphisms are associated with litter size in Small Tail Han sheep.Reproduction in domestic animals = Zuchthygiene · 2020Article
- Polymorphisms of the melatonin receptor 1A gene that affects the reproductive seasonality and litter size in Small Tail Han sheep.Reproduction in domestic animals = Zuchthygiene · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Previous researches have shown that MTNR1A plays an essential role in sheep reproduction. However, most researches focused more on the reproductive seasonality of sheep, and few scientists had studied the association of polymorphisms of the MTNR1A gene with ovine litter size and reproductive seasonality. Therefore, we chose MTNR1A gene to detect its novel sequence polymorphisms and population genetics and analyse their association with seasonal reproduction and litter size in ewes. The mRNA expression level in hypothalamus, pituitary and ovary was also detected. In this study, five polymorphisms (g.15118664G > T, g.15118683C > T, g.15118756C > T, g.15118774C > T and g.15118951G > A) were identified in exon 2. Most importantly, the g.15118683C > T and g.15118951G > A were significant difference between year-round oestrous sheep and seasonal oestrous sheep (p < .01), and g.15118756C > T had a great effect on litter size of Small Tail Han sheep (p < .05). In addition, the mRNA expression level of MTNR1A in the hypothalamus of polytocous Small Tail Han sheep was significantly higher than that in monotocous Small Tail Han sheep (p < .01) and the expression of MTNR1A in the hypothalamus of year-round oestrous sheep was significantly higher than that in seasonal oestrous sheep (p < .01). Polymorphisms in exon 2 may regulate the reproductive seasonality and litter size of ewes by influencing gene expression to regulate the reproductive seasonality and litter size of ewes. Our studies provided useful guidance in marker-assisted selection of the litter size in Small Tail Han sheep.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.