ArticleClinical transplantation2019
The association of post-lung transplant acute kidney injury with mortality is independent of primary graft dysfunction: A cohort study.
Article in Clinical transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Predicting Acute Kidney Injury After Lung Transplantation: Development and Internal Validation of Perioperative Prediction Models.Clinical transplantation · 2026Article
- A risk-score prediction of postoperative acute kidney injury following lung transplantation: a retrospective cohort study.Journal of cardiothoracic surgery · 2025Article
- Chronic Kidney Disease After Lung Transplantation in Spain: A Retrospective Single-Center Analysis.Journal of clinical medicine · 2025Article
- Immune mediators in heart-lung communication.Pflugers Archiv : European journal of physiology · 2025Review
- Investigating an appropriate indicator of acute kidney injury for patient prognosis following lung transplantation.Renal failure · 2024Article
- Development and validation of a population pharmacokinetic model to guide perioperative tacrolimus dosing after lung transplantation.JHLT open · 2024Article
- Interorgan communication networks in the kidney-lung axis.Nature reviews. Nephrology · 2024Review
- Pulmonary, circulatory and renal considerations in the early postoperative management of the lung transplant recipient.Global cardiology science & practice · 2023Review
- Primary graft dysfunction grade correlates with acute kidney injury stage after lung transplantation.Journal of thoracic disease · 2023Article
- Longitudinal assessment of renal function after lung transplantation for cystic fibrosis: transition from post-operative acute kidney injury to acute kidney disease and chronic kidney failure.Journal of nephrology · 2022Article
- Extracellular vesicles from lung tissue drive bone marrow neutrophil recruitment in inflammation.Journal of extracellular vesicles · 2022Article
- Early post-lung transplant calcineurin inhibitor management varies widely: An international survey.Clinical transplantation · 2022Article
- Acute kidney injury after lung transplantation: a narrative review.Annals of translational medicine · 2021Review
- The Effect of Monthly Anti-CD25International journal of organ transplantation medicine · 2020Article
- Acute Kidney Injury after Lung Transplantation: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2019Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPrior studies of post-lung transplant acute kidney injury (AKI) have not accounted for confounding effects of primary graft dysfunction (PGD). We sought to test the impact of PGD on AKI risk factors and on the association of AKI with mortality.
methodsWe included patients transplanted at the University of Pennsylvania from 2005-12, defined AKI using consensus criteria during transplant hospitalization, and defined PGD as grade 3 at 48-72 hours. We used multivariable logistic regression to test the impact of PGD on AKI risk factors and Cox models to test association of AKI with one-year mortality adjusting for PGD and other confounders.
resultsOf 299 patients, 188 (62.9%) developed AKI with 142 (75%) cases occurring by postoperative day 4. In multivariable models, PGD was strongly associated with AKI (OR 3.76, 95% CI 1.72-8.19, P = .001) but minimally changed associations of other risk factors with AKI. Both AKI (HR 3.64, 95% CI 1.68-7.88, P = .001) and PGD (HR 2.55, 95% CI 1.40-4.64, P = .002) were independently associated with one-year mortality.
conclusionsPost-lung transplant AKI risk factors and association of AKI with mortality were independent of PGD. AKI may therefore be a target for improving lung transplant mortality rather than simply an epiphenomenon of PGD.
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