ArticleCancer2019
Site of extranodal metastasis impacts survival in patients with testicular germ cell tumors.
Article in Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Intracardiac Extension of Testicular Germ Cell Tumor via the Left Superior Pulmonary Vein Mimicking Thrombus.JACC. Case reports · 2026Article
- Curative approach for solitary liver metastasis presenting as a rare pattern of organ spread in testicular cancer: a case report.International cancer conference journal · 2025Article
- Review
- Long-term Clinical Outcomes of Patients With Negative Pathology (pN0) at Primary Retroperitoneal Lymph Node Dissection.Clinical genitourinary cancer · 2024Article
- Driver mutations associated with signatures of platinum sensitivity in germ cell tumors.NPJ precision oncology · 2024Article
- Competing risk nomogram predicting cause-specific mortality in older patients with testicular germ cell tumors.Frontiers in medicine · 2024Article
- Non-invasive detection of orthotopic human lung tumors by microRNA expression profiling of mouse exhaled breath condensates and exhaled extracellular vesicles.Extracellular vesicles and circulating nucleic acids · 2024Article
- A decade in focus: mixed germ cell tumors with choriocarcinoma components.Annals of medicine and surgery (2012) · 2023Article
- Development and validation of a nomogram to predict lung metastasis in patients with testicular germ cell tumors.Heliyon · 2023Article
- Proposal for a Two-Tier Re-classification of Stage IV/M1 domain of Renal Cell Carcinoma into M1 ("Oligometastatic") and M2 ("Polymetastatic") subdomains: Analysis of the Registry for Metastatic Renal Cell Carcinoma (REMARCC).Frontiers in oncology · 2023Article
- Clinical features and prognostic factors in patients diagnosed with lymphovascular invasion of testicular germ-cell tumors: Analysis based on the SEER database.Frontiers in oncology · 2023Article
- Symptomatic spinal cord compression in spinal epidural metastasis of a testicular germ cell tumor: a case report with review of the literature.Annals of translational medicine · 2022Article
- Artificial Intelligence-Based Prognostic Model for Urologic Cancers: A SEER-Based Study.Cancers · 2022Article
- Peritoneal carcinosis in male germ cell tumor patients: a registry study compiled by the German Testicular Cancer Study Group (GTCSG).World journal of urology · 2022Article
- Testicular Germ-Cell Tumors with Spermatic Cord Involvement: A Retrospective International Multi-Institutional Experience.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022Article
- Characteristics of lung metastasis in testicular cancer: A large-scale population analysis based on propensity score matching.Frontiers in surgery · 2022Article
- Simultaneous intracranial and testicular germ cell tumors: illustrative case.Journal of neurosurgery. Case lessons · 2021Article
- Development and validation of a nomogram to predict survival in patients with metastatic testicular germ cell tumors.Translational cancer research · 2020Article
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8 authors.
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Abstract
backgroundUsing a large, nationally representative, population-based cancer registry, this study systematically evaluated the impact of the location and burden of extranodal testicular germ cell tumor (TGCT) metastases on survival.
methodsMen with stage III TGCTs captured by the Surveillance, Epidemiology, and End Results registry from 2010 to 2015 with distant extranodal metastases were identified. Clinicopathologic information was collected, and patients were subdivided according to the specific organ site or sites of metastatic involvement (lung, liver, bone, and/or brain). Kaplan-Meier analysis and multivariable Cox regression were used to evaluate cancer-specific survival (CSS), and model performance was assessed with Harrell's C statistic.
resultsNine hundred sixty-nine patients with stage III TGCTs were included with predominantly nonseminomatous histology (84%). Most patients (91%) had pulmonary metastases, whereas 20%, 10%, and 10% had liver, bone, and brain metastases, respectively. Over a median follow-up of 21 months, 19% of these men died of TGCTs. When they were grouped by the primary site of metastasis, patients with more than 1 extrapulmonary metastasis exhibited the worst CSS (hazard ratio [HR] vs isolated pulmonary involvement, 4.27; 95% confidence interval [CI], 2.60-7.00; P < .01). Among patients with isolated extrapulmonary involvement, those with brain metastases had the poorest survival (HR, 3.24; 95% CI, 1.98-5.28; P < .01), and they were followed by patients with liver (HR, 2.29; 95% CI, 1.56-3.35; P < .01) and bone metastases (HR, 1.97; 95% CI, 1.11-3.50; P = .02). Harrell's C statistic (multivariable) was 0.71.
conclusionsThe site of metastatic involvement affects survival outcomes for patients with TGCTs, and this may reflect both the aggressive biology and the challenging treatment of these tumors. Further incorporation of organotropism into current prognostic models for metastatic TGCTs warrants attention.
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