Evidence map›Paper›PMID 31355804›Full record

ArticleJournal of visualized experiments : JoVE2019

Enhancing the Engraftment of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes via a Transient Inhibition of Rho Kinase Activity.

Meng Zhao, Yawen Tang, Patrick J Ernst, Asher Kahn-Krell, Chengming Fan, Danielle Pretorius, Hanxi Zhu, Xi Lou, Lufang Zhou, Jianyi Zhang and 1 more

Abstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of visualized experiments : JoVE, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Meng ZhaoDepartment of Biomedical Engineering, School of Medicine, School of Engineering, University of Alabama at Birmingham.
Yawen TangDepartment of Biomedical Engineering, School of Medicine, School of Engineering, University of Alabama at Birmingham.
Patrick J ErnstDepartment of Biomedical Engineering, School of Medicine, School of Engineering, University of Alabama at Birmingham; Division of Cardiovascular Diseases, School of Medicine, School of Engineering, University of Alabama at Birmingham.
Asher Kahn-KrellDepartment of Biomedical Engineering, School of Medicine, School of Engineering, University of Alabama at Birmingham.
Chengming FanDepartment of Biomedical Engineering, School of Medicine, School of Engineering, University of Alabama at Birmingham; Department of Cardiac Surgery, The Second Xiangya Hospital of Central South University.
Danielle PretoriusDepartment of Biomedical Engineering, School of Medicine, School of Engineering, University of Alabama at Birmingham.
Hanxi ZhuDepartment of Biomedical Engineering, School of Medicine, School of Engineering, University of Alabama at Birmingham.
Xi LouDepartment of Biomedical Engineering, School of Medicine, School of Engineering, University of Alabama at Birmingham.
Lufang ZhouDivision of Cardiovascular Diseases, School of Medicine, School of Engineering, University of Alabama at Birmingham.
Jianyi ZhangDepartment of Biomedical Engineering, School of Medicine, School of Engineering, University of Alabama at Birmingham.
Wuqiang ZhuDepartment of Biomedical Engineering, School of Medicine, School of Engineering, University of Alabama at Birmingham; wzhu@uab.edu.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008361 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YACOUBIAN, TALENE ALENE · 1992 to 2024
$16.8M
Integrated Cellular and Tissue Engineering for Ischemic Heart DiseaseU01HL134764 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BURSAC, NENAD, KAMP, TIMOTHY J. · 2016 to 2022
$7.7M
Supplement of HL131017: Myocardial remuscularization by cardiac patch delivery of epicardial FSTL1 and CCND2 overexpressing cardiomyocytesR01HL131017 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SERPOOSHAN, VAHID, ZHANG, JIANYI · 2016 to 2025
$5.8M
Endogenous and exogenous mechanisms that promote myocardial remuscularization in post infarction LV remodelingR01HL114120 · NHLBI · UNIVERSITY OF MINNESOTA · PI ZHANG, JIANYI · 2012 to 2021
$5.6M
Stem Cells For Myocardial Repair: A Large Bore Magnet StudyR01HL095077 · NHLBI · UNIVERSITY OF MINNESOTA · PI ZHANG, JIANYI · 2009 to 2017
$3.8M
Mesenchymal Stem Cell Exosome in Efferocytosis of Apoptotic Cardiomyocytes and Repair after Myocardial IschemiaR01HL138023 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KRISHNAMURTHY, PRASANNA, ZHANG, JIANYI · 2018 to 2021
$2.6M
Mitochondria-SR Redox Signaling and Ca2+ Handling in Healthy and Failing HeartsR01HL121206 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ZHOU, LUFANG · 2015 to 2019
$1.8M
Myocardial Repair with a Novel Engineered Cardiac Muscle PatchR01HL142627 · NHLBI · MAYO CLINIC ARIZONA · PI ZHU, WUQIANG · 2019 to 2022
$1.7M
Myocardial Repair with a Novel Engineered Cardiac Muscle PatchR56HL142627 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ZHU, WUQIANG · 2018 to 2018
$371k
NHLBI NIH HHS R01 HL095077NHLBI NIH HHS R01 HL114120NHLBI NIH HHS R01 HL121206NHLBI NIH HHS R01 HL131017NHLBI NIH HHS R01 HL138023NHLBI NIH HHS R01 HL142627NHLBI NIH HHS R56 HL142627NHLBI NIH HHS U01 HL134764NIGMS NIH HHS T32 GM008361
6 · The paper itself

Abstract

A crucial factor in improving cellular therapy effectiveness for myocardial regeneration is to safely and efficiently increase the cell engraftment rate. Y-27632 is a highly potent inhibitor of Rho-associated, coiled-coil-containing protein kinase (RhoA/ROCK) and is used to prevent dissociation-induced cell apoptosis (anoikis). We demonstrate that Y-27632 pretreatment for human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs

Indexed as

AmidesAnimalsCell AdhesionCell Adhesion MoleculesCell DifferentiationCells, CulturedDisease Models, AnimalDown-RegulationHumansInduced Pluripotent Stem CellsMiceMyocardial InfarctionMyocytes, CardiacProtein SubunitsPyridinesrho-Associated KinasesAmidesCell Adhesion MoleculesProtein SubunitsPyridinesrho-Associated KinasesTroponinVerapamilY 27632

Identifiers

PMID31355804
PMCPMC8373436

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.