ArticleeLife2019
Spinal V2b neurons reveal a role for ipsilateral inhibition in speed control.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 62 citations in OpenAlex.
- Transcriptomic analysis of spinal V1 interneurons informs their multifunctional role in motor output.Nature communications · 2026Article
- Spatial and network principles behind neural generation of locomotion.Nature communications · 2026Article
- Redefining the central pattern generator for vertebrate locomotion.Nature reviews. Neuroscience · 2026Review
- Single-cell chromatin profiling reveals dynamic regulatory logic and enhancer elements in brain and retina development.bioRxiv : the preprint server for biology · 2026Article
- Article
- Coordinated spinal locomotor network dynamics emerge from cell-type-specific connectivity patterns.eLife · 2025Article
- Innovations in spinal cord cell type heterogeneity across vertebrate evolution.bioRxiv : the preprint server for biology · 2025Article
- V2b Neurons Act via Multiple Targets to Produce in Phase Inhibition during Locomotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Coordinated spinal locomotor network dynamics emerge from cell-type-specific connectivity patterns.bioRxiv : the preprint server for biology · 2025Article
- Review
- The spinal premotor network driving scratching flexor and extensor alternation.bioRxiv : the preprint server for biology · 2025Article
- Cell-type-specific origins of locomotor rhythmicity at different speeds in larval zebrafish.eLife · 2024Article
- Electrical Synapses Mediate Embryonic Hyperactivity in a Zebrafish Model of Fragile X Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Spinal Interneurons: Diversity and Connectivity in Motor Control.Annual review of neuroscience · 2023Review
- Impact of Endurance Training on Regeneration of Axons, Glial Cells, and Inhibitory Neurons after Spinal Cord Injury: A Link between Functional Outcome and Regeneration Potential within the Lesion Site and in Adjacent Spinal Cord Tissue.International journal of molecular sciences · 2023Article
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- Article
- Article
- Voltage imaging identifies spinal circuits that modulate locomotor adaptation in zebrafish.Neuron · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The spinal cord contains a diverse array of interneurons that govern motor output. Traditionally, models of spinal circuits have emphasized the role of inhibition in enforcing reciprocal alternation between left and right sides or flexors and extensors. However, recent work has shown that inhibition also increases coincident with excitation during contraction. Here, using larval zebrafish, we investigate the V2b (Gata3+) class of neurons, which contribute to flexor-extensor alternation but are otherwise poorly understood. Using newly generated transgenic lines we define two stable subclasses with distinct neurotransmitter and morphological properties. These V2b subclasses synapse directly onto motor neurons with differential targeting to speed-specific circuits. In vivo, optogenetic manipulation of V2b activity modulates locomotor frequency: suppressing V2b neurons elicits faster locomotion, whereas activating V2b neurons slows locomotion. We conclude that V2b neurons serve as a brake on axial motor circuits. Together, these results indicate a role for ipsilateral inhibition in speed control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.