ArticleeLife2019
Sub-second dynamics of theta-gamma coupling in hippocampal CA1.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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Who cites it
27 citing papers in PubMed.
- Medial entorhinal-hippocampal desynchronization parallels the emergence of memory impairment in a mouse model of Alzheimer's disease pathology.Cell reports · 2026Article
- When dreams feel real: the MÖBIUS model.Communications biology · 2026Review
- Bridging Model and Experiment in Systems Neuroscience with Cleo: The Closed-Loop, Electrophysiology, and Optophysiology Simulation Testbed.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Allothetic and idiothetic spatial cues control the multiplexed theta phase coding of place cells.Nature neuroscience · 2025Article
- Bridging model and experiment in systems neuroscience with Cleo: the Closed-Loop, Electrophysiology, and Optophysiology simulation testbed.bioRxiv : the preprint server for biology · 2025Article
- Article
- Bilateral integration in somatosensory cortex is controlled by behavioral relevance.Nature neuroscience · 2025Article
- Dynamic gamma modulation of hippocampal place cells predominates development of theta sequences.eLife · 2025Article
- Hippocampus shapes entorhinal cortical output through a direct feedback circuit.Nature neuroscience · 2025Article
- Gamma oscillatory complexity conveys behavioral information in hippocampal networks.Nature communications · 2024Article
- A machine learning approach for real-time cortical state estimation.Journal of neural engineering · 2024Article
- The medial septum controls hippocampal supra-theta oscillations.Nature communications · 2023Article
- Article
- Article
- Linking temporal coordination of hippocampal activity to memory function.Frontiers in cellular neuroscience · 2023Review
- Magnetoencephalography can reveal deep brain network activities linked to memory processes.Human brain mapping · 2022Article
- HectoSTAR μLED Optoelectrodes for Large-Scale, High-Precision In Vivo Opto-Electrophysiology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- A Variable Clock Underlies Internally Generated Hippocampal Sequences.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Goal discrimination in hippocampal nonplace cells when place information is ambiguous.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Golden rhythms as a theoretical framework for cross-frequency organization.Neurons, behavior, data analysis, and theory · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Oscillatory brain activity reflects different internal brain states including neurons' excitatory state and synchrony among neurons. However, characterizing these states is complicated by the fact that different oscillations are often coupled, such as gamma oscillations nested in theta in the hippocampus, and changes in coupling are thought to reflect distinct states. Here, we describe a new method to separate single oscillatory cycles into distinct states based on frequency and phase coupling. Using this method, we identified four theta-gamma coupling states in rat hippocampal CA1. These states differed in abundance across behaviors, phase synchrony with other hippocampal subregions, and neural coding properties suggesting that these states are functionally distinct. We captured cycle-to-cycle changes in oscillatory coupling states and found frequent switching between theta-gamma states showing that the hippocampus rapidly shifts between different functional states. This method provides a new approach to investigate oscillatory brain dynamics broadly.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.